Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time
Edible cassava leaves (Manihot esculenta) were consumed as vegetables for their bioactive compounds, however the effect of harvesting time on these bioactive compounds and their antidiabetic and anti-obesity inhibitory activities were scarcely reported in the literature. Phenolics from edible leaves...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | International Journal of Food Properties |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2022.2050256 |
| _version_ | 1818386194534236160 |
|---|---|
| author | Alphonse Laya Benoît B. Koubala Pradeep S. Negi |
| author_facet | Alphonse Laya Benoît B. Koubala Pradeep S. Negi |
| author_sort | Alphonse Laya |
| collection | DOAJ |
| description | Edible cassava leaves (Manihot esculenta) were consumed as vegetables for their bioactive compounds, however the effect of harvesting time on these bioactive compounds and their antidiabetic and anti-obesity inhibitory activities were scarcely reported in the literature. Phenolics from edible leaves harvested at different times were assessed using HPLC-DAD, and their antidiabetic and anti-obesity inhibitory activities were investigated before and after in vitro gastrointestinal digestion. The results showed a significant (P < .05) effect of harvesting time on phenolic contents. Bound phenolics showed higher lipase inhibitory activity than their free fractions. However, phenolic contents decreased after in vitro digestion, while they showed high antidiabetic and anti-obesity inhibitory activities. The present study demonstrated that edible leaves harvested at different times are rich in flavonoids, stilbenes, tannins and saponins. These bioactive compounds are highly potent against α-amylase, α-glucosidase and lipase before and after in vitro gastrointestinal digestion. Therefore, we recommend edible cassava leaves for important biological active compounds for the prevention of obesity and type 2 diabetes. |
| first_indexed | 2024-12-14T03:50:11Z |
| format | Article |
| id | doaj.art-5270a19db68149af8d44854466f1b7ee |
| institution | Directory Open Access Journal |
| issn | 1094-2912 1532-2386 |
| language | English |
| last_indexed | 2024-12-14T03:50:11Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj.art-5270a19db68149af8d44854466f1b7ee2022-12-21T23:18:15ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862022-12-0125149250810.1080/10942912.2022.2050256Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested timeAlphonse Laya0Benoît B. Koubala1Pradeep S. Negi2Department of Biology Faculty of Science, University of Maroua, Maroua, CameroonDepartment of Life and Earth Sciences, Higher Teachers’ Training College of Maroua, University of Maroua, Maroua, CameroonFruit and Vegetable Technology Department, CSIR-Central Food Technology Research Institute, Mysuru, IndiaEdible cassava leaves (Manihot esculenta) were consumed as vegetables for their bioactive compounds, however the effect of harvesting time on these bioactive compounds and their antidiabetic and anti-obesity inhibitory activities were scarcely reported in the literature. Phenolics from edible leaves harvested at different times were assessed using HPLC-DAD, and their antidiabetic and anti-obesity inhibitory activities were investigated before and after in vitro gastrointestinal digestion. The results showed a significant (P < .05) effect of harvesting time on phenolic contents. Bound phenolics showed higher lipase inhibitory activity than their free fractions. However, phenolic contents decreased after in vitro digestion, while they showed high antidiabetic and anti-obesity inhibitory activities. The present study demonstrated that edible leaves harvested at different times are rich in flavonoids, stilbenes, tannins and saponins. These bioactive compounds are highly potent against α-amylase, α-glucosidase and lipase before and after in vitro gastrointestinal digestion. Therefore, we recommend edible cassava leaves for important biological active compounds for the prevention of obesity and type 2 diabetes.https://www.tandfonline.com/doi/10.1080/10942912.2022.2050256Bound phenolicIn vitro gastrointestinal digestionantidiabeticManihot esculentaharvest timetype 2 diabetes |
| spellingShingle | Alphonse Laya Benoît B. Koubala Pradeep S. Negi Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time International Journal of Food Properties Bound phenolic In vitro gastrointestinal digestion antidiabetic Manihot esculenta harvest time type 2 diabetes |
| title | Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time |
| title_full | Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time |
| title_fullStr | Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time |
| title_full_unstemmed | Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time |
| title_short | Antidiabetic (α-amylase and α-glucosidase) and anti-obesity (lipase) inhibitory activities of edible cassava (Manihot esculenta Crantz) as measured by in vitro gastrointestinal digestion: effects of phenolics and harvested time |
| title_sort | antidiabetic α amylase and α glucosidase and anti obesity lipase inhibitory activities of edible cassava manihot esculenta crantz as measured by in vitro gastrointestinal digestion effects of phenolics and harvested time |
| topic | Bound phenolic In vitro gastrointestinal digestion antidiabetic Manihot esculenta harvest time type 2 diabetes |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2022.2050256 |
| work_keys_str_mv | AT alphonselaya antidiabeticaamylaseandaglucosidaseandantiobesitylipaseinhibitoryactivitiesofediblecassavamanihotesculentacrantzasmeasuredbyinvitrogastrointestinaldigestioneffectsofphenolicsandharvestedtime AT benoitbkoubala antidiabeticaamylaseandaglucosidaseandantiobesitylipaseinhibitoryactivitiesofediblecassavamanihotesculentacrantzasmeasuredbyinvitrogastrointestinaldigestioneffectsofphenolicsandharvestedtime AT pradeepsnegi antidiabeticaamylaseandaglucosidaseandantiobesitylipaseinhibitoryactivitiesofediblecassavamanihotesculentacrantzasmeasuredbyinvitrogastrointestinaldigestioneffectsofphenolicsandharvestedtime |