Aucubin alleviates diabetic nephropathy by inhibiting NF-κB activation and inducing SIRT1/SIRT3-FOXO3a signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

Aucubin alleviates diabetic nephropathy by inhibiting NF-κB activation and inducing SIRT1/SIRT3-FOXO3a signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

Oxidative stress and inflammation are two important pathological mechanisms in diabetic nephropathy (DN). Aucubin (AU), a natural iridoid glucoside, possessing remarkable anti-inflammatory and anti-oxidation activity, has been used to treat diabetic complications. However, underlying mechanism of pr...

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Bibliographic Details
Main Authors: Bo Ma, Zhiming Zhu, Jie Zhang, Chaoxing Ren, Qi Zhang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Functional Foods
Subjects:
Aucubin
Diabetic nephropathy
FOXO3a
NF-κB
Oxidative stress
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464619306267

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