Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital
Abstract Background House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-08-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43168-021-00082-x |
| _version_ | 1818601123996499968 |
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| author | Nahla Mohamed Okasha Amr Ali Sarhan Engy Osman Ahmed |
| author_facet | Nahla Mohamed Okasha Amr Ali Sarhan Engy Osman Ahmed |
| author_sort | Nahla Mohamed Okasha |
| collection | DOAJ |
| description | Abstract Background House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines. Results The most frequent clinical phenotype among the HDM-positive group was a cough (96.7%), while the clinical phenotypic wheeze was frequent in HDM negative group (96.7%). There is a statistically significant difference between studied cases classified according to sensitivity to HDM regarding level of asthma control (50.0% were uncontrolled among cases sensitive to HDM and 56.7% of cases non-sensitive to HDM were controlled (p = 0.001*). Severity according to treatment results was significantly higher among cases sensitive to HDM (26.7% of cases sensitive to HDM versus 3.3% of cases non-sensitive to HDM), p = 0.017. Conclusions HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis in our studied cases. HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms. Trial registration ClinicalTrial.gov, NCT04958616. |
| first_indexed | 2024-12-16T12:46:23Z |
| format | Article |
| id | doaj.art-52731dd7075d4b33a79fe350fab0e89a |
| institution | Directory Open Access Journal |
| issn | 1687-8426 2314-8551 |
| language | English |
| last_indexed | 2024-12-16T12:46:23Z |
| publishDate | 2021-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-52731dd7075d4b33a79fe350fab0e89a2022-12-21T22:31:16ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512021-08-011511710.1186/s43168-021-00082-xAssociation between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s HospitalNahla Mohamed Okasha0Amr Ali Sarhan1Engy Osman Ahmed2Pediatric Department, Mansoura University Faculty of MedicineNephrology Unit, Mansoura University Faculty of MedicineAllergy and Pediatric Pulmonology Unit, Mansoura University Faculty of MedicineAbstract Background House dust mites (HDM) are considered as a major source of indoor aeroallergen all over the world that precipitate allergic reactions including rhinoconjunctivitis, food allergy, atopic dermatitis, and allergic asthma. In this study, we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according to recent GINA guidelines. Results The most frequent clinical phenotype among the HDM-positive group was a cough (96.7%), while the clinical phenotypic wheeze was frequent in HDM negative group (96.7%). There is a statistically significant difference between studied cases classified according to sensitivity to HDM regarding level of asthma control (50.0% were uncontrolled among cases sensitive to HDM and 56.7% of cases non-sensitive to HDM were controlled (p = 0.001*). Severity according to treatment results was significantly higher among cases sensitive to HDM (26.7% of cases sensitive to HDM versus 3.3% of cases non-sensitive to HDM), p = 0.017. Conclusions HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis in our studied cases. HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms. Trial registration ClinicalTrial.gov, NCT04958616.https://doi.org/10.1186/s43168-021-00082-xAsthma severityDermatophagoides farinaDermatophagoides pteronyssinusSpirometry |
| spellingShingle | Nahla Mohamed Okasha Amr Ali Sarhan Engy Osman Ahmed Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital The Egyptian Journal of Bronchology Asthma severity Dermatophagoides farina Dermatophagoides pteronyssinus Spirometry |
| title | Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital |
| title_full | Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital |
| title_fullStr | Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital |
| title_full_unstemmed | Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital |
| title_short | Association between house dust mites sensitization and level of asthma control and severity in children attending Mansoura University Children’s Hospital |
| title_sort | association between house dust mites sensitization and level of asthma control and severity in children attending mansoura university children s hospital |
| topic | Asthma severity Dermatophagoides farina Dermatophagoides pteronyssinus Spirometry |
| url | https://doi.org/10.1186/s43168-021-00082-x |
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