Spectrum and functional properties of <i>ERG11</i> gene mutations in fluconazole-resistant <i>Candida albicans</i> strains isolated from HIV-infected patients

Spectrum and functional properties of <i>ERG11</i> gene mutations in fluconazole-resistant <i>Candida albicans</i> strains isolated from HIV-infected patients

Rationale. The low efficacy of azole antimycotics in treatment of Candida infections, especially in HIV-infected patients, is often associated with overexpression of the ERG11 gene in Candida spp., which results in increased production of ergosterol the target of the above antimycotic drugs. Resear...

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Main Authors: Yuri V. Nesvizhsky, Stanislav S. Afanasiev, Alexander D. Voropaev, Yulia N. Urban, Mariam E. Suleimanova, Maxim S. Afanasiev, Elena V. Budanova, Elena A. Voropaeva
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2023-09-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
candida
erg11 gene
mutations
resistance to antimycotic agents
hiv infection
Online Access:https://microbiol.crie.ru/jour/article/viewFile/17278/1322

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