Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved]
This review highlights advances made in recent years in the diagnosis and management of acute pancreatitis (AP). We focus on epidemiological, clinical, and management aspects of AP. Additionally, we discuss the role of using risk stratification tools to guide clinical decision making. The majority o...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2019-01-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-959/v2 |
| _version_ | 1819080045684064256 |
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| author | Amar Mandalia Erik-Jan Wamsteker Matthew J. DiMagno |
| author_facet | Amar Mandalia Erik-Jan Wamsteker Matthew J. DiMagno |
| author_sort | Amar Mandalia |
| collection | DOAJ |
| description | This review highlights advances made in recent years in the diagnosis and management of acute pancreatitis (AP). We focus on epidemiological, clinical, and management aspects of AP. Additionally, we discuss the role of using risk stratification tools to guide clinical decision making. The majority of patients suffer from mild AP, and only a subset develop moderately severe AP, defined as a pancreatic local complication, or severe AP, defined as persistent organ failure. In mild AP, management typically involves diagnostic evaluation and supportive care resulting usually in a short hospital length of stay (LOS). In severe AP, a multidisciplinary approach is warranted to minimize morbidity and mortality over the course of a protracted hospital LOS. Based on evidence from guideline recommendations, we discuss five treatment interventions, including intravenous fluid resuscitation, feeding, prophylactic antibiotics, probiotics, and timing of endoscopic retrograde cholangiopancreatography (ERCP) in acute biliary pancreatitis. This review also highlights the importance of preventive interventions to reduce hospital readmission or prevent pancreatitis, including alcohol and smoking cessation, same-admission cholecystectomy for acute biliary pancreatitis, and chemoprevention and fluid administration for post-ERCP pancreatitis. Our review aims to consolidate guideline recommendations and high-quality studies published in recent years to guide the management of AP and highlight areas in need of research. |
| first_indexed | 2024-12-21T19:38:39Z |
| format | Article |
| id | doaj.art-5274556adcb2474a940d78287975a487 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-21T19:38:39Z |
| publishDate | 2019-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-5274556adcb2474a940d78287975a4872022-12-21T18:52:32ZengF1000 Research LtdF1000Research2046-14022019-01-01710.12688/f1000research.14244.219478Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved]Amar Mandalia0Erik-Jan Wamsteker1Matthew J. DiMagno2Division of Gastroenterology and Hepatology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USADivision of Gastroenterology and Hepatology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USADivision of Gastroenterology and Hepatology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USAThis review highlights advances made in recent years in the diagnosis and management of acute pancreatitis (AP). We focus on epidemiological, clinical, and management aspects of AP. Additionally, we discuss the role of using risk stratification tools to guide clinical decision making. The majority of patients suffer from mild AP, and only a subset develop moderately severe AP, defined as a pancreatic local complication, or severe AP, defined as persistent organ failure. In mild AP, management typically involves diagnostic evaluation and supportive care resulting usually in a short hospital length of stay (LOS). In severe AP, a multidisciplinary approach is warranted to minimize morbidity and mortality over the course of a protracted hospital LOS. Based on evidence from guideline recommendations, we discuss five treatment interventions, including intravenous fluid resuscitation, feeding, prophylactic antibiotics, probiotics, and timing of endoscopic retrograde cholangiopancreatography (ERCP) in acute biliary pancreatitis. This review also highlights the importance of preventive interventions to reduce hospital readmission or prevent pancreatitis, including alcohol and smoking cessation, same-admission cholecystectomy for acute biliary pancreatitis, and chemoprevention and fluid administration for post-ERCP pancreatitis. Our review aims to consolidate guideline recommendations and high-quality studies published in recent years to guide the management of AP and highlight areas in need of research.https://f1000research.com/articles/7-959/v2 |
| spellingShingle | Amar Mandalia Erik-Jan Wamsteker Matthew J. DiMagno Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved] F1000Research |
| title | Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved] |
| title_full | Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved] |
| title_fullStr | Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved] |
| title_full_unstemmed | Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved] |
| title_short | Recent advances in understanding and managing acute pancreatitis [version 2; referees: 2 approved] |
| title_sort | recent advances in understanding and managing acute pancreatitis version 2 referees 2 approved |
| url | https://f1000research.com/articles/7-959/v2 |
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