5-HT Receptors and the Development of New Antidepressants
Serotonin modulates several physiological and cognitive pathways throughout the human body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the serotonergic system and interactions with other neurochemical systems indicate that the development of depression may be m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/9015 |
| _version_ | 1797523495493566464 |
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| author | Grzegorz Ślifirski Marek Król Jadwiga Turło |
| author_facet | Grzegorz Ślifirski Marek Król Jadwiga Turło |
| author_sort | Grzegorz Ślifirski |
| collection | DOAJ |
| description | Serotonin modulates several physiological and cognitive pathways throughout the human body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the serotonergic system and interactions with other neurochemical systems indicate that the development of depression may be mediated by various pathomechanisms, the common denominator of which is undoubtedly the disturbed transmission in central 5-HT synapses. Therefore, the deliberate pharmacological modulation of serotonergic transmission in the brain seems to be one of the most appropriate strategies for the search for new antidepressants. As discussed in this review, the serotonergic system offers great potential for the development of new antidepressant therapies based on the combination of SERT inhibition with different pharmacological activity towards the 5-HT system. The aim of this article is to summarize the search for new antidepressants in recent years, focusing primarily on the possibility of benefiting from interactions with various 5-HT receptors in the pharmacotherapy of depression. |
| first_indexed | 2024-03-10T08:43:48Z |
| format | Article |
| id | doaj.art-52752607d33c44b5a329796d0fc497ec |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:43:48Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-52752607d33c44b5a329796d0fc497ec2023-11-22T08:04:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216901510.3390/ijms221690155-HT Receptors and the Development of New AntidepressantsGrzegorz Ślifirski0Marek Król1Jadwiga Turło2Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, PolandDepartment of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, PolandDepartment of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, PolandSerotonin modulates several physiological and cognitive pathways throughout the human body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the serotonergic system and interactions with other neurochemical systems indicate that the development of depression may be mediated by various pathomechanisms, the common denominator of which is undoubtedly the disturbed transmission in central 5-HT synapses. Therefore, the deliberate pharmacological modulation of serotonergic transmission in the brain seems to be one of the most appropriate strategies for the search for new antidepressants. As discussed in this review, the serotonergic system offers great potential for the development of new antidepressant therapies based on the combination of SERT inhibition with different pharmacological activity towards the 5-HT system. The aim of this article is to summarize the search for new antidepressants in recent years, focusing primarily on the possibility of benefiting from interactions with various 5-HT receptors in the pharmacotherapy of depression.https://www.mdpi.com/1422-0067/22/16/9015antidepressantsdrug designdual 5-HT<sub>1A</sub>/SERT activitymultimodal activity |
| spellingShingle | Grzegorz Ślifirski Marek Król Jadwiga Turło 5-HT Receptors and the Development of New Antidepressants International Journal of Molecular Sciences antidepressants drug design dual 5-HT<sub>1A</sub>/SERT activity multimodal activity |
| title | 5-HT Receptors and the Development of New Antidepressants |
| title_full | 5-HT Receptors and the Development of New Antidepressants |
| title_fullStr | 5-HT Receptors and the Development of New Antidepressants |
| title_full_unstemmed | 5-HT Receptors and the Development of New Antidepressants |
| title_short | 5-HT Receptors and the Development of New Antidepressants |
| title_sort | 5 ht receptors and the development of new antidepressants |
| topic | antidepressants drug design dual 5-HT<sub>1A</sub>/SERT activity multimodal activity |
| url | https://www.mdpi.com/1422-0067/22/16/9015 |
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