Use of Testing for West Nile Virus and Other Arboviruses
In the United States, the most commonly diagnosed arboviral disease is West Nile virus (WNV) infection. Diagnosis is made by detecting WNV IgG or viral genomic sequences in serum or cerebrospinal fluid. To determine frequency of this testing in WNV-endemic areas, we examined the proportion of tests...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2016-09-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/22/9/15-2050_article |
| _version_ | 1811270666761011200 |
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| author | Jakapat Vanichanan Lucrecia Salazar Susan H. Wootton Elizabeth Aguilera Melissa N. Garcia Kristy O. Murray Rodrigo Hasbun |
| author_facet | Jakapat Vanichanan Lucrecia Salazar Susan H. Wootton Elizabeth Aguilera Melissa N. Garcia Kristy O. Murray Rodrigo Hasbun |
| author_sort | Jakapat Vanichanan |
| collection | DOAJ |
| description | In the United States, the most commonly diagnosed arboviral disease is West Nile virus (WNV) infection. Diagnosis is made by detecting WNV IgG or viral genomic sequences in serum or cerebrospinal fluid. To determine frequency of this testing in WNV-endemic areas, we examined the proportion of tests ordered for patients with meningitis and encephalitis at 9 hospitals in Houston, Texas, USA. We identified 751 patients (567 adults, 184 children), among whom 390 (52%) experienced illness onset during WNV season (June–October). WNV testing was ordered for 281 (37%) of the 751; results indicated acute infection for 32 (11%). Characteristics associated with WNV testing were acute focal neurologic deficits; older age; magnetic resonance imaging; empirically prescribed antiviral therapy; worse clinical outcomes: and concomitant testing for mycobacterial, fungal, or other viral infections. Testing for WNV is underutilized, and testing of patients with more severe disease raises the possibility of diagnostic bias in epidemiologic studies. |
| first_indexed | 2024-04-12T22:07:22Z |
| format | Article |
| id | doaj.art-52765d55b2f34fa8bdb480179ffa05d3 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T22:07:22Z |
| publishDate | 2016-09-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-52765d55b2f34fa8bdb480179ffa05d32022-12-22T03:14:54ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-09-012291587159310.3201/eid2209.152050Use of Testing for West Nile Virus and Other ArbovirusesJakapat VanichananLucrecia SalazarSusan H. WoottonElizabeth AguileraMelissa N. GarciaKristy O. MurrayRodrigo HasbunIn the United States, the most commonly diagnosed arboviral disease is West Nile virus (WNV) infection. Diagnosis is made by detecting WNV IgG or viral genomic sequences in serum or cerebrospinal fluid. To determine frequency of this testing in WNV-endemic areas, we examined the proportion of tests ordered for patients with meningitis and encephalitis at 9 hospitals in Houston, Texas, USA. We identified 751 patients (567 adults, 184 children), among whom 390 (52%) experienced illness onset during WNV season (June–October). WNV testing was ordered for 281 (37%) of the 751; results indicated acute infection for 32 (11%). Characteristics associated with WNV testing were acute focal neurologic deficits; older age; magnetic resonance imaging; empirically prescribed antiviral therapy; worse clinical outcomes: and concomitant testing for mycobacterial, fungal, or other viral infections. Testing for WNV is underutilized, and testing of patients with more severe disease raises the possibility of diagnostic bias in epidemiologic studies.https://wwwnc.cdc.gov/eid/article/22/9/15-2050_articlemeningitisencephalitiscommunity-acquired CNS infectionsWest Nile virus testingarboviral diseaseviruses |
| spellingShingle | Jakapat Vanichanan Lucrecia Salazar Susan H. Wootton Elizabeth Aguilera Melissa N. Garcia Kristy O. Murray Rodrigo Hasbun Use of Testing for West Nile Virus and Other Arboviruses Emerging Infectious Diseases meningitis encephalitis community-acquired CNS infections West Nile virus testing arboviral disease viruses |
| title | Use of Testing for West Nile Virus and Other Arboviruses |
| title_full | Use of Testing for West Nile Virus and Other Arboviruses |
| title_fullStr | Use of Testing for West Nile Virus and Other Arboviruses |
| title_full_unstemmed | Use of Testing for West Nile Virus and Other Arboviruses |
| title_short | Use of Testing for West Nile Virus and Other Arboviruses |
| title_sort | use of testing for west nile virus and other arboviruses |
| topic | meningitis encephalitis community-acquired CNS infections West Nile virus testing arboviral disease viruses |
| url | https://wwwnc.cdc.gov/eid/article/22/9/15-2050_article |
| work_keys_str_mv | AT jakapatvanichanan useoftestingforwestnilevirusandotherarboviruses AT lucreciasalazar useoftestingforwestnilevirusandotherarboviruses AT susanhwootton useoftestingforwestnilevirusandotherarboviruses AT elizabethaguilera useoftestingforwestnilevirusandotherarboviruses AT melissangarcia useoftestingforwestnilevirusandotherarboviruses AT kristyomurray useoftestingforwestnilevirusandotherarboviruses AT rodrigohasbun useoftestingforwestnilevirusandotherarboviruses |