The Role of the Adipokines in the Most Common Gestational Complications
Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of v...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9408 |
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| author | Paweł Gutaj Rafał Sibiak Maurycy Jankowski Karina Awdi Rut Bryl Paul Mozdziak Bartosz Kempisty Ewa Wender-Ozegowska |
| author_facet | Paweł Gutaj Rafał Sibiak Maurycy Jankowski Karina Awdi Rut Bryl Paul Mozdziak Bartosz Kempisty Ewa Wender-Ozegowska |
| author_sort | Paweł Gutaj |
| collection | DOAJ |
| description | Adipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans. |
| first_indexed | 2024-03-10T14:10:39Z |
| format | Article |
| id | doaj.art-5278124c38684987bec3acd3dfd8035b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:10:39Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5278124c38684987bec3acd3dfd8035b2023-11-21T00:11:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124940810.3390/ijms21249408The Role of the Adipokines in the Most Common Gestational ComplicationsPaweł Gutaj0Rafał Sibiak1Maurycy Jankowski2Karina Awdi3Rut Bryl4Paul Mozdziak5Bartosz Kempisty6Ewa Wender-Ozegowska7Department of Reproduction, Chair of Obstetrics, Gynecology, and Gynecologic Oncology, Poznań University of Medical Sciences, 60-535 Poznan, PolandDepartment of Reproduction, Chair of Obstetrics, Gynecology, and Gynecologic Oncology, Poznań University of Medical Sciences, 60-535 Poznan, PolandDepartment of Anatomy, Poznań University of Medical Sciences, 60-781 Poznan, PolandStudent’s Scientific Society, Poznan University of Medical Sciences, 60-806 Poznan, PolandDepartment of Anatomy, Poznań University of Medical Sciences, 60-781 Poznan, PolandPhysiology Graduate Program, North Carolina State University, Raleigh, NC 27695-7608, USADepartment of Histology and Embryology, Poznań University of Medical Sciences, 60-781 Poznan, PolandDepartment of Reproduction, Chair of Obstetrics, Gynecology, and Gynecologic Oncology, Poznań University of Medical Sciences, 60-535 Poznan, PolandAdipocytokines are hormonally active molecules that are believed to play a key role in the regulation of crucial biological processes in the human body. Numerous experimental studies established significant alterations in the adipokine secretion patterns throughout pregnancy. The exact etiology of various gestational complications, such as gestational diabetes, preeclampsia, and fetal growth abnormalities, needs to be fully elucidated. The discovery of adipokines raised questions about their potential contribution to the molecular pathophysiology of those diseases. Multiple studies analyzed their local mRNA expression and circulating protein levels. However, most studies report conflicting results. Several adipokines such as leptin, resistin, irisin, apelin, chemerin, and omentin were proposed as potential novel early markers of heterogeneous gestational complications. The inclusion of the adipokines in the standard predictive multifactorial models could improve their prognostic values. Nonetheless, their independent diagnostic value is mostly insufficient to be implemented into standard clinical practice. Routine assessments of adipokine levels during pregnancy are not recommended in the management of both normal and complicated pregnancies. Based on the animal models (e.g., apelin and its receptors in the rodent preeclampsia models), future implementation of adipokines and their receptors as new therapeutic targets appears promising but requires further validation in humans.https://www.mdpi.com/1422-0067/21/24/9408adiponectinapelinchemeringestational diabetesirisinleptin |
| spellingShingle | Paweł Gutaj Rafał Sibiak Maurycy Jankowski Karina Awdi Rut Bryl Paul Mozdziak Bartosz Kempisty Ewa Wender-Ozegowska The Role of the Adipokines in the Most Common Gestational Complications International Journal of Molecular Sciences adiponectin apelin chemerin gestational diabetes irisin leptin |
| title | The Role of the Adipokines in the Most Common Gestational Complications |
| title_full | The Role of the Adipokines in the Most Common Gestational Complications |
| title_fullStr | The Role of the Adipokines in the Most Common Gestational Complications |
| title_full_unstemmed | The Role of the Adipokines in the Most Common Gestational Complications |
| title_short | The Role of the Adipokines in the Most Common Gestational Complications |
| title_sort | role of the adipokines in the most common gestational complications |
| topic | adiponectin apelin chemerin gestational diabetes irisin leptin |
| url | https://www.mdpi.com/1422-0067/21/24/9408 |
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