Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components
Investigating the impact of diet on public health using risk–benefit assessment (RBA) methods that simultaneously consider both beneficial and adverse health outcomes could be useful for shaping dietary policies and guidelines. In the field of food safety and nutrition, RBA is a relatively new appro...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.951369/full |
| _version_ | 1811333267581829120 |
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| author | Géraldine Boué Ermolaos Ververis Ermolaos Ververis Aikaterini Niforou Michel Federighi Michel Federighi Sara M. Pires Morten Poulsen Sofie T. Thomsen Androniki Naska |
| author_facet | Géraldine Boué Ermolaos Ververis Ermolaos Ververis Aikaterini Niforou Michel Federighi Michel Federighi Sara M. Pires Morten Poulsen Sofie T. Thomsen Androniki Naska |
| author_sort | Géraldine Boué |
| collection | DOAJ |
| description | Investigating the impact of diet on public health using risk–benefit assessment (RBA) methods that simultaneously consider both beneficial and adverse health outcomes could be useful for shaping dietary policies and guidelines. In the field of food safety and nutrition, RBA is a relatively new approach facing methodological challenges and being subject to further developments. One of the methodological aspects calling for improvement is the selection of components to be considered in the assessment, currently based mainly on non-harmonized unstandardized experts’ judgment. Our aim was to develop a harmonized, transparent, and documented methodological framework for selecting nutritional, microbiological, and toxicological RBA components. The approach was developed under the Novel foods as red meat replacers—an insight using Risk-Benefit Assessment methods (NovRBA) case study, which attempted to estimate the overall health impact of replacing red meat with an edible insect species, Acheta domesticus. Starting from the compositional profiles of both food items, we created a “long list” of food components. By subsequently applying a series of predefined criteria, we proceeded from the “long” to the “short list.” These criteria were established based on the occurrence and severity of health outcomes related to these components. For nutrition and microbiology, the occurrence of health outcomes was evaluated considering the presence of a component in the raw material, as well as the effect of processing on the respective component. Regarding toxicology, the presence and exposure relative to reference doses and the contribution to total exposure were considered. Severity was graded with the potential contribution to the background diet alongside bioavailability aspects (nutrition), the disability-adjusted life years per case of illness of each hazard (microbiology), and disease incidence in the population, potential fatality, and lifelong disability (toxicology). To develop the “final list” of components, the “short list” was refined by considering the availability and quality of data for a feasible inclusion in the RBA model. The methodology developed can be broadly used in food RBA, to guide and reinforce a harmonized selection of nutritional, microbiological, and toxicological components and will contribute to facilitating RBA implementation, enabling the generation of transparent, robust, and comparable outcomes. |
| first_indexed | 2024-04-13T16:49:59Z |
| format | Article |
| id | doaj.art-52784b35f6ff4efa8bf15b69180eb44a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T16:49:59Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-52784b35f6ff4efa8bf15b69180eb44a2022-12-22T02:38:58ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.951369951369Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological componentsGéraldine Boué0Ermolaos Ververis1Ermolaos Ververis2Aikaterini Niforou3Michel Federighi4Michel Federighi5Sara M. Pires6Morten Poulsen7Sofie T. Thomsen8Androniki Naska9Oniris, INRAE, SECALIM, Nantes, FranceDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, GreeceEuropean Food Safety Authority, Parma, ItalyDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, GreeceOniris, INRAE, SECALIM, Nantes, FranceENVA, ANSES, LSA, Maisons-Alfort, FranceRisk Benefit Research Group, National Food Institute/DTU, Lyngby, DenmarkRisk Benefit Research Group, National Food Institute/DTU, Lyngby, DenmarkRisk Benefit Research Group, National Food Institute/DTU, Lyngby, DenmarkDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, GreeceInvestigating the impact of diet on public health using risk–benefit assessment (RBA) methods that simultaneously consider both beneficial and adverse health outcomes could be useful for shaping dietary policies and guidelines. In the field of food safety and nutrition, RBA is a relatively new approach facing methodological challenges and being subject to further developments. One of the methodological aspects calling for improvement is the selection of components to be considered in the assessment, currently based mainly on non-harmonized unstandardized experts’ judgment. Our aim was to develop a harmonized, transparent, and documented methodological framework for selecting nutritional, microbiological, and toxicological RBA components. The approach was developed under the Novel foods as red meat replacers—an insight using Risk-Benefit Assessment methods (NovRBA) case study, which attempted to estimate the overall health impact of replacing red meat with an edible insect species, Acheta domesticus. Starting from the compositional profiles of both food items, we created a “long list” of food components. By subsequently applying a series of predefined criteria, we proceeded from the “long” to the “short list.” These criteria were established based on the occurrence and severity of health outcomes related to these components. For nutrition and microbiology, the occurrence of health outcomes was evaluated considering the presence of a component in the raw material, as well as the effect of processing on the respective component. Regarding toxicology, the presence and exposure relative to reference doses and the contribution to total exposure were considered. Severity was graded with the potential contribution to the background diet alongside bioavailability aspects (nutrition), the disability-adjusted life years per case of illness of each hazard (microbiology), and disease incidence in the population, potential fatality, and lifelong disability (toxicology). To develop the “final list” of components, the “short list” was refined by considering the availability and quality of data for a feasible inclusion in the RBA model. The methodology developed can be broadly used in food RBA, to guide and reinforce a harmonized selection of nutritional, microbiological, and toxicological components and will contribute to facilitating RBA implementation, enabling the generation of transparent, robust, and comparable outcomes.https://www.frontiersin.org/articles/10.3389/fnut.2022.951369/fullRBAnutritionfood safetyalternative proteinsedible insectsrisk assessment |
| spellingShingle | Géraldine Boué Ermolaos Ververis Ermolaos Ververis Aikaterini Niforou Michel Federighi Michel Federighi Sara M. Pires Morten Poulsen Sofie T. Thomsen Androniki Naska Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components Frontiers in Nutrition RBA nutrition food safety alternative proteins edible insects risk assessment |
| title | Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components |
| title_full | Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components |
| title_fullStr | Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components |
| title_full_unstemmed | Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components |
| title_short | Risk–Benefit assessment of foods: Development of a methodological framework for the harmonized selection of nutritional, microbiological, and toxicological components |
| title_sort | risk benefit assessment of foods development of a methodological framework for the harmonized selection of nutritional microbiological and toxicological components |
| topic | RBA nutrition food safety alternative proteins edible insects risk assessment |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.951369/full |
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