Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway

Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway

Abstract Background Autoimmune thyroiditis (AIT) with euthyroid is associated with miscarriage. But the exact mechanism remains unclear. Studies have shown that the programmed cell death-1 (PD-1)/programmed cell death -ligand 1 (PD-L1) pathway is essential for normal pregnancy. However, the expressi...

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Bibliographic Details
Main Authors: Mengya Chen, Nduwimana Gilbert, Haixia Liu
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Reproductive Biology and Endocrinology
Subjects:
PD-1/PD-L1
AIT
Placenta
Invasion
ERK1/2
Online Access:http://link.springer.com/article/10.1186/s12958-019-0536-1

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