Extracellular Vesicles as Regulators of the Extracellular Matrix
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EV...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/10/2/136 |
| _version_ | 1827758545000464384 |
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| author | Neil J. Patel Anisa Ashraf Eun Ji Chung |
| author_facet | Neil J. Patel Anisa Ashraf Eun Ji Chung |
| author_sort | Neil J. Patel |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined. |
| first_indexed | 2024-03-11T09:08:52Z |
| format | Article |
| id | doaj.art-527afed389a84f66b7171b4258b93035 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T09:08:52Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-527afed389a84f66b7171b4258b930352023-11-16T19:10:04ZengMDPI AGBioengineering2306-53542023-01-0110213610.3390/bioengineering10020136Extracellular Vesicles as Regulators of the Extracellular MatrixNeil J. Patel0Anisa Ashraf1Eun Ji Chung2Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USADepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USADepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USAExtracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EVs interact with the extracellular matrix (ECM) which acts as a physical scaffold for the organization and function of cells. Recent work has shown that EVs can modulate and act as regulators of the ECM. This review will first discuss EV biogenesis and the mechanism by which EVs are transported through the ECM. Additionally, we discuss how EVs contribute as structural components of the matrix and as components that aid in the degradation of the ECM. Lastly, the role of EVs in influencing recipient cells to remodel the ECM in both pathological and therapeutic contexts is examined.https://www.mdpi.com/2306-5354/10/2/136extracellular vesiclesextracellular matrixtissue repaircalcificationtumor microenvironment |
| spellingShingle | Neil J. Patel Anisa Ashraf Eun Ji Chung Extracellular Vesicles as Regulators of the Extracellular Matrix Bioengineering extracellular vesicles extracellular matrix tissue repair calcification tumor microenvironment |
| title | Extracellular Vesicles as Regulators of the Extracellular Matrix |
| title_full | Extracellular Vesicles as Regulators of the Extracellular Matrix |
| title_fullStr | Extracellular Vesicles as Regulators of the Extracellular Matrix |
| title_full_unstemmed | Extracellular Vesicles as Regulators of the Extracellular Matrix |
| title_short | Extracellular Vesicles as Regulators of the Extracellular Matrix |
| title_sort | extracellular vesicles as regulators of the extracellular matrix |
| topic | extracellular vesicles extracellular matrix tissue repair calcification tumor microenvironment |
| url | https://www.mdpi.com/2306-5354/10/2/136 |
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