PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia

Abstract Background Chemotherapy induces a cachectic‐like phenotype, accompanied by skeletal muscle wasting, weakness and mitochondrial dysfunction. Peroxisome proliferator‐activated receptor‐gamma coactivator‐1 alpha (PGC1α), a regulator of mitochondrial biogenesis, is often reduced in cachectic sk...

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Bibliographic Details
Main Authors: Joshua R. Huot, Fabrizio Pin, Rohit Chatterjee, Andrea Bonetto
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Skeletal muscle
Cisplatin
Chemotherapy
PGC1α
cachexia
Online Access:https://doi.org/10.1002/jcsm.13035

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