Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy
Introduction: Adenoid hypertrophy is a common childhood disease; its standard treatment is adenoidectomy. The desire for medical management is increasing due to fewer complications and more convenience. The present study investigated the effect of adding oral montelukast to mometasone nasal spray in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2024-03-01
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| Series: | Iranian Journal of Otorhinolaryngology |
| Subjects: | |
| Online Access: | https://ijorl.mums.ac.ir/article_23907_6d9b32dddc174fa5062b8b77619c3701.pdf |
| _version_ | 1797205568155287552 |
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| author | Mohsen Jafari Bahar Pourroshani Kambiz Eftekhari Armen Malekiantaghi Parisa Ashournia Alireza Shafiei |
| author_facet | Mohsen Jafari Bahar Pourroshani Kambiz Eftekhari Armen Malekiantaghi Parisa Ashournia Alireza Shafiei |
| author_sort | Mohsen Jafari |
| collection | DOAJ |
| description | Introduction: Adenoid hypertrophy is a common childhood disease; its standard treatment is adenoidectomy. The desire for medical management is increasing due to fewer complications and more convenience. The present study investigated the effect of adding oral montelukast to mometasone nasal spray in treating adenoid hypertrophy.
Materials and Methods: This was a randomized, double-blind, placebo-controlled study conducted at a referral teaching hospital (Tehran, Iran) from September 2020 to September 2021. Children aged 2 to 14 years with clinical and radiological findings of adenoid hypertrophy were enrolled. Patients were randomly divided into two groups: mometasone nasal spray with oral montelukast (case group) or mometasone with placebo (control group). Then, the clinical scores were compared before and two months after the intervention.
Results: Ninety-six patients completed the study [62.5% male (n=60)]. Of these, 51 were in the case and 45 in the control group. The clinical score in each group decreased significantly after the intervention (P<0.001), but the decrease in clinical score in the case group was not significantly different from the control (p=0.576).
Conclusion: The results showed that the combination therapy with mometasone and montelukast has the same efficacy as mometasone and placebo in treating adenoid hypertrophy. Adding montelukast to mometasone has no additional effect. |
| first_indexed | 2024-04-24T08:53:11Z |
| format | Article |
| id | doaj.art-527ec9cb962240ebbe05fe7c1d9e8ee2 |
| institution | Directory Open Access Journal |
| issn | 2251-7251 2251-726X |
| language | English |
| last_indexed | 2024-04-24T08:53:11Z |
| publishDate | 2024-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Otorhinolaryngology |
| spelling | doaj.art-527ec9cb962240ebbe05fe7c1d9e8ee22024-04-16T09:04:12ZengMashhad University of Medical SciencesIranian Journal of Otorhinolaryngology2251-72512251-726X2024-03-0136239139710.22038/ijorl.2024.73906.349023907Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid HypertrophyMohsen Jafari0Bahar Pourroshani1Kambiz Eftekhari2Armen Malekiantaghi3Parisa Ashournia4Alireza Shafiei5Division of Infectious Diseases, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.Pediatric Gastroenterology and Hepatology Research Center, Division of Gastroenterology, Department of Pediatric, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.Division of Gastroenterology, Department of Pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.Division of Allergy and Clinical Immunology, Department of Pediatrics, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.Introduction: Adenoid hypertrophy is a common childhood disease; its standard treatment is adenoidectomy. The desire for medical management is increasing due to fewer complications and more convenience. The present study investigated the effect of adding oral montelukast to mometasone nasal spray in treating adenoid hypertrophy. Materials and Methods: This was a randomized, double-blind, placebo-controlled study conducted at a referral teaching hospital (Tehran, Iran) from September 2020 to September 2021. Children aged 2 to 14 years with clinical and radiological findings of adenoid hypertrophy were enrolled. Patients were randomly divided into two groups: mometasone nasal spray with oral montelukast (case group) or mometasone with placebo (control group). Then, the clinical scores were compared before and two months after the intervention. Results: Ninety-six patients completed the study [62.5% male (n=60)]. Of these, 51 were in the case and 45 in the control group. The clinical score in each group decreased significantly after the intervention (P<0.001), but the decrease in clinical score in the case group was not significantly different from the control (p=0.576). Conclusion: The results showed that the combination therapy with mometasone and montelukast has the same efficacy as mometasone and placebo in treating adenoid hypertrophy. Adding montelukast to mometasone has no additional effect.https://ijorl.mums.ac.ir/article_23907_6d9b32dddc174fa5062b8b77619c3701.pdfadenoidchildrenmometasone furoatemontelukast |
| spellingShingle | Mohsen Jafari Bahar Pourroshani Kambiz Eftekhari Armen Malekiantaghi Parisa Ashournia Alireza Shafiei Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy Iranian Journal of Otorhinolaryngology adenoid children mometasone furoate montelukast |
| title | Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy |
| title_full | Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy |
| title_fullStr | Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy |
| title_full_unstemmed | Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy |
| title_short | Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy |
| title_sort | effect of combination montelukast and nasal mometasone on childhood adenoid hypertrophy |
| topic | adenoid children mometasone furoate montelukast |
| url | https://ijorl.mums.ac.ir/article_23907_6d9b32dddc174fa5062b8b77619c3701.pdf |
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