Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses
Background: Little is known about the vaccine effectiveness (VE) in attenuating the influenza-associated symptoms in children during the 2014–2015 influenza season in Beijing, China, in which there was a mismatch between the vaccine and circulating strain. Methods: This study included 210 laboratory...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-05-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1575573 |
| _version_ | 1797677403832582144 |
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| author | Wei Duan Li Zhang Shuangsheng Wu Chunna Ma Ying Sun Man Zhang Yi Zhang Xingxing Zhang Quanyi Wang Peng Yang |
| author_facet | Wei Duan Li Zhang Shuangsheng Wu Chunna Ma Ying Sun Man Zhang Yi Zhang Xingxing Zhang Quanyi Wang Peng Yang |
| author_sort | Wei Duan |
| collection | DOAJ |
| description | Background: Little is known about the vaccine effectiveness (VE) in attenuating the influenza-associated symptoms in children during the 2014–2015 influenza season in Beijing, China, in which there was a mismatch between the vaccine and circulating strain. Methods: This study included 210 laboratory-confirmed influenza cases among children, who were enrolled in 2014, from November 1 to December 31. Standard demographic information and clinical symptoms were recorded. Influenza vaccination was confirmed via a vaccination registry. Univariate and multivariate analyses were used to estimate the odds of presenting with clinical symptoms among vaccinated and unvaccinated groups, adjusting for sex, age, area, BMI level, and chronic conditions. Results: Among the 210 laboratory-confirmed influenza cases, 170 (81.0%) presented with fever ≥38°C. The other most common symptoms were cough (78.1%), sore throat (46.7%), nasal congestion/rhinorrhea (38.6%), headache (34.8%), fatigue (24.8%) and myalgia/arthralgia (16.2%). Approximately 9.0% (19/210) exhibited nausea/vomiting, and 2.4% (5/210) exhibited diarrhea/abdominal pain. Respiratory complications occurred in 5.7% (12/210) of the confirmed influenza cases. In 210 laboratory-confirmed cases, univariate and multivariate conducted after adjusted for the aforementioned characteristics suggested that the odds of fever ≥ 38°C were significantly reduced in vaccinated children (odds ratio [OR]: 0.42, 95% CI: 0.19–0.93; P = 0.033). Conclusions: Influenza vaccination may reduce the clinical symptoms of laboratory-confirmed influenza cases potentially even in the mismatching season. |
| first_indexed | 2024-03-11T22:44:44Z |
| format | Article |
| id | doaj.art-528122a1100c4d2e90efad98020b3396 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:44:44Z |
| publishDate | 2019-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-528122a1100c4d2e90efad98020b33962023-09-22T08:38:26ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2019-05-011551031103410.1080/21645515.2019.15755731575573Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 virusesWei Duan0Li Zhang1Shuangsheng Wu2Chunna Ma3Ying Sun4Man Zhang5Yi Zhang6Xingxing Zhang7Quanyi Wang8Peng Yang9Beijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBeijing Center for Disease Prevention and ControlBackground: Little is known about the vaccine effectiveness (VE) in attenuating the influenza-associated symptoms in children during the 2014–2015 influenza season in Beijing, China, in which there was a mismatch between the vaccine and circulating strain. Methods: This study included 210 laboratory-confirmed influenza cases among children, who were enrolled in 2014, from November 1 to December 31. Standard demographic information and clinical symptoms were recorded. Influenza vaccination was confirmed via a vaccination registry. Univariate and multivariate analyses were used to estimate the odds of presenting with clinical symptoms among vaccinated and unvaccinated groups, adjusting for sex, age, area, BMI level, and chronic conditions. Results: Among the 210 laboratory-confirmed influenza cases, 170 (81.0%) presented with fever ≥38°C. The other most common symptoms were cough (78.1%), sore throat (46.7%), nasal congestion/rhinorrhea (38.6%), headache (34.8%), fatigue (24.8%) and myalgia/arthralgia (16.2%). Approximately 9.0% (19/210) exhibited nausea/vomiting, and 2.4% (5/210) exhibited diarrhea/abdominal pain. Respiratory complications occurred in 5.7% (12/210) of the confirmed influenza cases. In 210 laboratory-confirmed cases, univariate and multivariate conducted after adjusted for the aforementioned characteristics suggested that the odds of fever ≥ 38°C were significantly reduced in vaccinated children (odds ratio [OR]: 0.42, 95% CI: 0.19–0.93; P = 0.033). Conclusions: Influenza vaccination may reduce the clinical symptoms of laboratory-confirmed influenza cases potentially even in the mismatching season.http://dx.doi.org/10.1080/21645515.2019.1575573influenzavaccinationsymptomsoutbreakschoolchildren |
| spellingShingle | Wei Duan Li Zhang Shuangsheng Wu Chunna Ma Ying Sun Man Zhang Yi Zhang Xingxing Zhang Quanyi Wang Peng Yang Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses Human Vaccines & Immunotherapeutics influenza vaccination symptoms outbreak school children |
| title | Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses |
| title_full | Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses |
| title_fullStr | Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses |
| title_full_unstemmed | Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses |
| title_short | Reduction of influenza A(H3N2)-associated symptoms by influenza vaccination in school aged-children during the 2014-2015 winter season dominated by mismatched H3N2 viruses |
| title_sort | reduction of influenza a h3n2 associated symptoms by influenza vaccination in school aged children during the 2014 2015 winter season dominated by mismatched h3n2 viruses |
| topic | influenza vaccination symptoms outbreak school children |
| url | http://dx.doi.org/10.1080/21645515.2019.1575573 |
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