Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza
Avian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency...
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Format: | Article |
Language: | English |
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Centers for Disease Control and Prevention
2008-01-01
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Series: | Emerging Infectious Diseases |
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Online Access: | https://wwwnc.cdc.gov/eid/article/14/1/06-1283_article |
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author | Cristiana Gioia Concetta Castilletti Massimo Tempestilli Paola Piacentini Licia Bordi Roberta Chiappini Chiara Agrati Salvatore Squarcione Giuseppe Ippolito Vincenzo Puro Maria Rosaria Capobianchi Fabrizio Poccia |
author_facet | Cristiana Gioia Concetta Castilletti Massimo Tempestilli Paola Piacentini Licia Bordi Roberta Chiappini Chiara Agrati Salvatore Squarcione Giuseppe Ippolito Vincenzo Puro Maria Rosaria Capobianchi Fabrizio Poccia |
author_sort | Cristiana Gioia |
collection | DOAJ |
description | Avian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specific for subtype H5N1 was detected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against influenza (H5N1) in a large number of donors. No correlation between influenza-specific CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination. |
first_indexed | 2024-04-12T01:45:56Z |
format | Article |
id | doaj.art-528392e30fb5475b940d1dc7afe72e73 |
institution | Directory Open Access Journal |
issn | 1080-6040 1080-6059 |
language | English |
last_indexed | 2024-04-12T01:45:56Z |
publishDate | 2008-01-01 |
publisher | Centers for Disease Control and Prevention |
record_format | Article |
series | Emerging Infectious Diseases |
spelling | doaj.art-528392e30fb5475b940d1dc7afe72e732022-12-22T03:53:05ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592008-01-0114112112810.3201/eid1401.061283Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for InfluenzaCristiana GioiaConcetta CastillettiMassimo TempestilliPaola PiacentiniLicia BordiRoberta ChiappiniChiara AgratiSalvatore SquarcioneGiuseppe IppolitoVincenzo PuroMaria Rosaria CapobianchiFabrizio PocciaAvian influenza virus (H5N1) can be transmitted to humans, resulting in a severe or fatal disease. The aim of this study was to evaluate the immune cross-reactivity between human and avian influenza (H5N1) strains in healthy donors vaccinated for seasonal influenza A (H1N1)/(H3N2). A small frequency of CD4 T cells specific for subtype H5N1 was detected in several persons at baseline, and seasonal vaccine administration enhanced the frequency of such reactive CD4 T cells. We also observed that seasonal vaccination is able to raise neutralizing immunity against influenza (H5N1) in a large number of donors. No correlation between influenza-specific CD4 T cells and humoral responses was observed. N1 may possibly be a target for both cellular and humoral cross-type immunity, but additional experiments are needed to clarify this point. These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination.https://wwwnc.cdc.gov/eid/article/14/1/06-1283_articleHeterotypic immunityvaccinationhuman influenzaavian influenzaresearchItaly |
spellingShingle | Cristiana Gioia Concetta Castilletti Massimo Tempestilli Paola Piacentini Licia Bordi Roberta Chiappini Chiara Agrati Salvatore Squarcione Giuseppe Ippolito Vincenzo Puro Maria Rosaria Capobianchi Fabrizio Poccia Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza Emerging Infectious Diseases Heterotypic immunity vaccination human influenza avian influenza research Italy |
title | Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza |
title_full | Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza |
title_fullStr | Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza |
title_full_unstemmed | Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza |
title_short | Cross-subtype Immunity against Avian Influenza in Persons Recently Vaccinated for Influenza |
title_sort | cross subtype immunity against avian influenza in persons recently vaccinated for influenza |
topic | Heterotypic immunity vaccination human influenza avian influenza research Italy |
url | https://wwwnc.cdc.gov/eid/article/14/1/06-1283_article |
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