ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
Psoriatic arthritis is a chronic progressive disease of joints developing along with psoriasis. Likewise arthritis and psoriasis alone, it represents the systemic multifactorial disease of unknown etiology; therefore prevention of the disease is inefficient. Genetic predisposition to psoriatic arthr...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/915 |
| _version_ | 1797237684127662080 |
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| author | M. V. Smolnikova S. V. Smirnova |
| author_facet | M. V. Smolnikova S. V. Smirnova |
| author_sort | M. V. Smolnikova |
| collection | DOAJ |
| description | Psoriatic arthritis is a chronic progressive disease of joints developing along with psoriasis. Likewise arthritis and psoriasis alone, it represents the systemic multifactorial disease of unknown etiology; therefore prevention of the disease is inefficient. Genetic predisposition to psoriatic arthritis development is proposed with essential role of genes coding for cytokines, the main mediators of immune response. A study of the prevalence of polymorphisms of the genes of anti-inflammatory cytokines IL4 (C-590T) and IL10 (C-597A) in patients with psoriasis, psoriatic arthritis and healthy donors was carried out. The prevalence of the polymorphisms in the European population of Krasnoyarsk was obtained. An association of the C-590T polymorphic marker of the promoter region of the IL4 gene with psoriatic arthritis was established. The obtained results suggest that the C-590 allele is a contributing factor to heavier course of psoriasis and the development of bone system pathology. |
| first_indexed | 2024-03-08T12:23:01Z |
| format | Article |
| id | doaj.art-5284335d8ff14a11a7c25d173f21b4a3 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:23:39Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-5284335d8ff14a11a7c25d173f21b4a32024-03-28T07:49:04ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)190193861ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITISM. V. Smolnikova0S. V. Smirnova1Institute of Medical Problems of the North SB RAMSInstitute of Medical Problems of the North SB RAMSPsoriatic arthritis is a chronic progressive disease of joints developing along with psoriasis. Likewise arthritis and psoriasis alone, it represents the systemic multifactorial disease of unknown etiology; therefore prevention of the disease is inefficient. Genetic predisposition to psoriatic arthritis development is proposed with essential role of genes coding for cytokines, the main mediators of immune response. A study of the prevalence of polymorphisms of the genes of anti-inflammatory cytokines IL4 (C-590T) and IL10 (C-597A) in patients with psoriasis, psoriatic arthritis and healthy donors was carried out. The prevalence of the polymorphisms in the European population of Krasnoyarsk was obtained. An association of the C-590T polymorphic marker of the promoter region of the IL4 gene with psoriatic arthritis was established. The obtained results suggest that the C-590 allele is a contributing factor to heavier course of psoriasis and the development of bone system pathology.https://www.actabiomedica.ru/jour/article/view/915genes polymorphismpsoriatic arthritisinterleukin |
| spellingShingle | M. V. Smolnikova S. V. Smirnova ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS Acta Biomedica Scientifica genes polymorphism psoriatic arthritis interleukin |
| title | ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS |
| title_full | ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS |
| title_fullStr | ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS |
| title_full_unstemmed | ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS |
| title_short | ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS |
| title_sort | association between polymorphic markers of the il4 с 590т and il10 с 597а genes and psoriatic arthritis |
| topic | genes polymorphism psoriatic arthritis interleukin |
| url | https://www.actabiomedica.ru/jour/article/view/915 |
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