B cells in head and neck squamous cell carcinoma: current opinion and novel therapy
Abstract Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which have improved the prognosis of most patients, a subset of patients with poor prognoses still exist due to loss of surgical opportunities, postope...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-024-03218-3 |
| _version_ | 1827377120995704832 |
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| author | Xinyue Guo Licheng Xu Luan Nie Chenyu Zhang Yaohui Liu Rui Zhao Jing Cao Linli Tian Ming Liu |
| author_facet | Xinyue Guo Licheng Xu Luan Nie Chenyu Zhang Yaohui Liu Rui Zhao Jing Cao Linli Tian Ming Liu |
| author_sort | Xinyue Guo |
| collection | DOAJ |
| description | Abstract Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which have improved the prognosis of most patients, a subset of patients with poor prognoses still exist due to loss of surgical opportunities, postoperative recurrence, and metastasis, among other reasons. The tumour microenvironment (TME) is a complex organization composed of tumour, stromal, and endothelial cells. Communication and interaction between tumours and immune cells within the TME are increasingly being recognized as pivotal in inhibiting or promoting tumour development. Previous studies on T cells in the TME of HNSCC have yielded novel therapeutic possibilities. However, the function of B cells, another adaptive immune cell type, in the TME of HNSCC patients has yet to be determined. Recent studies have revealed various distinct subtypes of B cells and tertiary lymphoid structures (TLSs) in the TME of HNSCC patients, which are believed to impact the efficacy of immune checkpoint inhibitors (ICIs). Therefore, this paper focuses on B cells in the TME to explore potential directions for future immunotherapy for HNSCC. |
| first_indexed | 2024-03-08T12:34:19Z |
| format | Article |
| id | doaj.art-5284ff82b98249428017ee3d77753e63 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-08T12:34:19Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-5284ff82b98249428017ee3d77753e632024-01-21T12:36:16ZengBMCCancer Cell International1475-28672024-01-012411810.1186/s12935-024-03218-3B cells in head and neck squamous cell carcinoma: current opinion and novel therapyXinyue Guo0Licheng Xu1Luan Nie2Chenyu Zhang3Yaohui Liu4Rui Zhao5Jing Cao6Linli Tian7Ming Liu8Department of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical UniversityDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Harbin Medical UniversityAbstract Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumour. Despite advancements in surgery, radiotherapy and chemotherapy, which have improved the prognosis of most patients, a subset of patients with poor prognoses still exist due to loss of surgical opportunities, postoperative recurrence, and metastasis, among other reasons. The tumour microenvironment (TME) is a complex organization composed of tumour, stromal, and endothelial cells. Communication and interaction between tumours and immune cells within the TME are increasingly being recognized as pivotal in inhibiting or promoting tumour development. Previous studies on T cells in the TME of HNSCC have yielded novel therapeutic possibilities. However, the function of B cells, another adaptive immune cell type, in the TME of HNSCC patients has yet to be determined. Recent studies have revealed various distinct subtypes of B cells and tertiary lymphoid structures (TLSs) in the TME of HNSCC patients, which are believed to impact the efficacy of immune checkpoint inhibitors (ICIs). Therefore, this paper focuses on B cells in the TME to explore potential directions for future immunotherapy for HNSCC.https://doi.org/10.1186/s12935-024-03218-3HNSCCTMEB cellTherapyPrognosis |
| spellingShingle | Xinyue Guo Licheng Xu Luan Nie Chenyu Zhang Yaohui Liu Rui Zhao Jing Cao Linli Tian Ming Liu B cells in head and neck squamous cell carcinoma: current opinion and novel therapy Cancer Cell International HNSCC TME B cell Therapy Prognosis |
| title | B cells in head and neck squamous cell carcinoma: current opinion and novel therapy |
| title_full | B cells in head and neck squamous cell carcinoma: current opinion and novel therapy |
| title_fullStr | B cells in head and neck squamous cell carcinoma: current opinion and novel therapy |
| title_full_unstemmed | B cells in head and neck squamous cell carcinoma: current opinion and novel therapy |
| title_short | B cells in head and neck squamous cell carcinoma: current opinion and novel therapy |
| title_sort | b cells in head and neck squamous cell carcinoma current opinion and novel therapy |
| topic | HNSCC TME B cell Therapy Prognosis |
| url | https://doi.org/10.1186/s12935-024-03218-3 |
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