Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex.
In the fecal immunological test, a suitable cut-off value may be selected to classify results as either positive or negative. Our aim is to estimate the optimal cut-off value for detecting colorectal cancer in different age and sex groups. This is a multicentric retrospective cohort study of partici...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0254021 |
| _version_ | 1818401622476193792 |
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| author | Mercedes Vanaclocha-Espi Josefa Ibáñez Ana Molina-Barceló María José Valverde-Roig Andreu Nolasco Francisco Pérez-Riquelme Mariola de la Vega Isabel Portillo Dolores Salas |
| author_facet | Mercedes Vanaclocha-Espi Josefa Ibáñez Ana Molina-Barceló María José Valverde-Roig Andreu Nolasco Francisco Pérez-Riquelme Mariola de la Vega Isabel Portillo Dolores Salas |
| author_sort | Mercedes Vanaclocha-Espi |
| collection | DOAJ |
| description | In the fecal immunological test, a suitable cut-off value may be selected to classify results as either positive or negative. Our aim is to estimate the optimal cut-off value for detecting colorectal cancer in different age and sex groups. This is a multicentric retrospective cohort study of participants in CRC screening programs with FIT between 2006 and 2012. A total of 545,505 participations were analyzed. Cancers diagnosed outside of the program were identified after a negative test result (IC_test) up until 2014. The Wilcoxon test was used to compare fecal hemoglobin levels. ROC curves were used to identify the optimal cut-off value for each age and sex group. Screening program results were estimated for different cut-off values. The results show that the Hb concentration was higher in colorectal cancer (average = 179.6μg/g) vs. false positives (average = 55.2μg/g), in IC_test (average = 3.1μg/g) vs. true negatives (average = 0μg/g), and in men (average = 166.2μg/g) vs. women (average = 140.2μg/g) with colorectal cancer. The optimal cut-off values for women were 18.3μg/g (50-59y) and 14.6μg/g (60-69y), and 16.8μg/g (50-59y) and 19.9μg/g (60-69y) for men. Using different cut-off values for each age and sex group lead to a decrease in the IC_test rate compared to the 20μg/g cut-off value (from 0.40‰ to 0.37‰) and an increase in the false positive rate (from 6.45% to 6.99%). Moreover, test sensitivity improved (90.7%), especially in men and women aged 50-59y (89.4%; 90%) and women aged 60-69y (90.2%). In conclusion, the optimal cut-off value varies for different sex and age groups and the use of an optimal cut-off value for each group improves sensitivity and leads to a small decrease in IC_tests, but also to a larger increase in false positives. |
| first_indexed | 2024-12-14T07:55:24Z |
| format | Article |
| id | doaj.art-52859f6ec1d64455b662710308217b1f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:55:24Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-52859f6ec1d64455b662710308217b1f2022-12-21T23:10:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01167e025402110.1371/journal.pone.0254021Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex.Mercedes Vanaclocha-EspiJosefa IbáñezAna Molina-BarcelóMaría José Valverde-RoigAndreu NolascoFrancisco Pérez-RiquelmeMariola de la VegaIsabel PortilloDolores SalasIn the fecal immunological test, a suitable cut-off value may be selected to classify results as either positive or negative. Our aim is to estimate the optimal cut-off value for detecting colorectal cancer in different age and sex groups. This is a multicentric retrospective cohort study of participants in CRC screening programs with FIT between 2006 and 2012. A total of 545,505 participations were analyzed. Cancers diagnosed outside of the program were identified after a negative test result (IC_test) up until 2014. The Wilcoxon test was used to compare fecal hemoglobin levels. ROC curves were used to identify the optimal cut-off value for each age and sex group. Screening program results were estimated for different cut-off values. The results show that the Hb concentration was higher in colorectal cancer (average = 179.6μg/g) vs. false positives (average = 55.2μg/g), in IC_test (average = 3.1μg/g) vs. true negatives (average = 0μg/g), and in men (average = 166.2μg/g) vs. women (average = 140.2μg/g) with colorectal cancer. The optimal cut-off values for women were 18.3μg/g (50-59y) and 14.6μg/g (60-69y), and 16.8μg/g (50-59y) and 19.9μg/g (60-69y) for men. Using different cut-off values for each age and sex group lead to a decrease in the IC_test rate compared to the 20μg/g cut-off value (from 0.40‰ to 0.37‰) and an increase in the false positive rate (from 6.45% to 6.99%). Moreover, test sensitivity improved (90.7%), especially in men and women aged 50-59y (89.4%; 90%) and women aged 60-69y (90.2%). In conclusion, the optimal cut-off value varies for different sex and age groups and the use of an optimal cut-off value for each group improves sensitivity and leads to a small decrease in IC_tests, but also to a larger increase in false positives.https://doi.org/10.1371/journal.pone.0254021 |
| spellingShingle | Mercedes Vanaclocha-Espi Josefa Ibáñez Ana Molina-Barceló María José Valverde-Roig Andreu Nolasco Francisco Pérez-Riquelme Mariola de la Vega Isabel Portillo Dolores Salas Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex. PLoS ONE |
| title | Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex. |
| title_full | Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex. |
| title_fullStr | Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex. |
| title_full_unstemmed | Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex. |
| title_short | Optimal cut-off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex. |
| title_sort | optimal cut off value for detecting colorectal cancer with fecal immunochemical tests according to age and sex |
| url | https://doi.org/10.1371/journal.pone.0254021 |
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