Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which is caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β (Aβ) plaques and neurofibrillary tangles of Tau proteins. Thus, researchers have been devoting tremendous efforts to develo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/12/3879 |
| _version_ | 1797483929237716992 |
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| author | Haijun Yang Fantian Zeng Yunchun Luo Chao Zheng Chongzhao Ran Jian Yang |
| author_facet | Haijun Yang Fantian Zeng Yunchun Luo Chao Zheng Chongzhao Ran Jian Yang |
| author_sort | Haijun Yang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which is caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β (Aβ) plaques and neurofibrillary tangles of Tau proteins. Thus, researchers have been devoting tremendous efforts to developing and designing new molecules for the early diagnosis of AD and curative purposes. Curcumin and its scaffold have fluorescent and photochemical properties. Mounting evidence showed that curcumin scaffold had neuroprotective effects on AD such as anti-amyloidogenic, anti-inflammatory, anti-oxidative and metal chelating. In this review, we summarized different curcumin derivatives and analyzed the in vitro and in vivo results in order to exhibit the applications in AD diagnosis, therapeutic monitoring and therapy. The analysis results showed that, although curcumin and its analogues have some disadvantages such as short wavelength and low bioavailability, these shortcomings can be conquered by modifying the structures. Curcumin scaffold still has the potential to be a multifunctional tool for AD research, including AD diagnosis and therapy. |
| first_indexed | 2024-03-09T22:55:03Z |
| format | Article |
| id | doaj.art-5287387324ee43ffb8c3814a9e12b0f4 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T22:55:03Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5287387324ee43ffb8c3814a9e12b0f42023-11-23T18:13:01ZengMDPI AGMolecules1420-30492022-06-012712387910.3390/molecules27123879Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease ResearchHaijun Yang0Fantian Zeng1Yunchun Luo2Chao Zheng3Chongzhao Ran4Jian Yang5Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, ChinaSchool of Public Health, Xiamen University, Xiamen 361000, ChinaShanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, ChinaPET Center, School of Medicine, Yale University, New Haven, CT 06520, USAAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USAShanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai 200444, ChinaAlzheimer’s disease (AD) is one of the most common neurodegenerative disorders, which is caused by multi-factors and characterized by two histopathological hallmarks: amyloid-β (Aβ) plaques and neurofibrillary tangles of Tau proteins. Thus, researchers have been devoting tremendous efforts to developing and designing new molecules for the early diagnosis of AD and curative purposes. Curcumin and its scaffold have fluorescent and photochemical properties. Mounting evidence showed that curcumin scaffold had neuroprotective effects on AD such as anti-amyloidogenic, anti-inflammatory, anti-oxidative and metal chelating. In this review, we summarized different curcumin derivatives and analyzed the in vitro and in vivo results in order to exhibit the applications in AD diagnosis, therapeutic monitoring and therapy. The analysis results showed that, although curcumin and its analogues have some disadvantages such as short wavelength and low bioavailability, these shortcomings can be conquered by modifying the structures. Curcumin scaffold still has the potential to be a multifunctional tool for AD research, including AD diagnosis and therapy.https://www.mdpi.com/1420-3049/27/12/3879Alzheimer’s diseaseamyloid-βtau proteincurcumin scaffoldAD diagnosis |
| spellingShingle | Haijun Yang Fantian Zeng Yunchun Luo Chao Zheng Chongzhao Ran Jian Yang Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research Molecules Alzheimer’s disease amyloid-β tau protein curcumin scaffold AD diagnosis |
| title | Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research |
| title_full | Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research |
| title_fullStr | Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research |
| title_full_unstemmed | Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research |
| title_short | Curcumin Scaffold as a Multifunctional Tool for Alzheimer’s Disease Research |
| title_sort | curcumin scaffold as a multifunctional tool for alzheimer s disease research |
| topic | Alzheimer’s disease amyloid-β tau protein curcumin scaffold AD diagnosis |
| url | https://www.mdpi.com/1420-3049/27/12/3879 |
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