Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back
ATP-dependent chromatin remodeling is the active displacement of nucleosomes along or off DNA induced by chromatin remodeling complexes. This key process of gene regulation in eukaryote organisms has recently been argued to be controlled by a kinetic proofreading mechanism. In this paper we present...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2015-08-01
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| Series: | AIMS Biophysics |
| Subjects: | |
| Online Access: | http://www.aimspress.com/biophysics/article/407/fulltext.html |
| _version_ | 1818174541122240512 |
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| author | Raghvendra P Singh Guillaume Brysbaert Marc F Lensink Fabrizio Cleri Ralf Blossey |
| author_facet | Raghvendra P Singh Guillaume Brysbaert Marc F Lensink Fabrizio Cleri Ralf Blossey |
| author_sort | Raghvendra P Singh |
| collection | DOAJ |
| description | ATP-dependent chromatin remodeling is the active displacement of nucleosomes along or off DNA induced by chromatin remodeling complexes. This key process of gene regulation in eukaryote organisms has recently been argued to be controlled by a kinetic proofreading mechanism. In this paper we present a discussion of the current understanding of this process. We review the case of gene repression via heterochromatin formation by remodelers from the ISWI family and then discuss the activation of the IFN-<em>β</em> gene, where the displacement of the nucleosome is initiated by histone tail acetylations by the enzyme GCN5 which are required for the recruitment of SWI-SNF remodelers. We quantify the speci city of the acetylation step in the remodeling process by peptide docking simulations. |
| first_indexed | 2024-12-11T19:46:02Z |
| format | Article |
| id | doaj.art-528a18cd264b477c8ae8710f0eef3927 |
| institution | Directory Open Access Journal |
| issn | 2377-9098 |
| language | English |
| last_indexed | 2024-12-11T19:46:02Z |
| publishDate | 2015-08-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Biophysics |
| spelling | doaj.art-528a18cd264b477c8ae8710f0eef39272022-12-22T00:52:54ZengAIMS PressAIMS Biophysics2377-90982015-08-012439841110.3934/biophy.2015.4.398201504398Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and backRaghvendra P SinghGuillaume Brysbaert0Marc F Lensink1Fabrizio Cleri2Ralf Blossey3University of Lille, CNRS UMR 8576 Unit´e de Glycobiologie Structurale et Fonctionnelle(UGSF) and FRABio FR3688, 59000 Lille, FrancUniversity of Lille, CNRS UMR 8576 Unit´e de Glycobiologie Structurale et Fonctionnelle(UGSF) and FRABio FR3688, 59000 Lille, FrancUniversity of Lille, CNRS UMR8520, Institut d'Electronique, de Micro electronique et de Nanotechnologie (IEMN), 59000 Lille, FrancUniversity of Lille, CNRS UMR 8576 Unit´e de Glycobiologie Structurale et Fonctionnelle(UGSF) and FRABio FR3688, 59000 Lille, FrancATP-dependent chromatin remodeling is the active displacement of nucleosomes along or off DNA induced by chromatin remodeling complexes. This key process of gene regulation in eukaryote organisms has recently been argued to be controlled by a kinetic proofreading mechanism. In this paper we present a discussion of the current understanding of this process. We review the case of gene repression via heterochromatin formation by remodelers from the ISWI family and then discuss the activation of the IFN-<em>β</em> gene, where the displacement of the nucleosome is initiated by histone tail acetylations by the enzyme GCN5 which are required for the recruitment of SWI-SNF remodelers. We quantify the speci city of the acetylation step in the remodeling process by peptide docking simulations.http://www.aimspress.com/biophysics/article/407/fulltext.htmlchromatinhistone coderemodelerbromodomainnucleosomehistone |
| spellingShingle | Raghvendra P Singh Guillaume Brysbaert Marc F Lensink Fabrizio Cleri Ralf Blossey Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back AIMS Biophysics chromatin histone code remodeler bromodomain nucleosome histone |
| title | Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back |
| title_full | Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back |
| title_fullStr | Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back |
| title_full_unstemmed | Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back |
| title_short | Kinetic proofreading of chromatin remodeling: from gene activation to gene repression and back |
| title_sort | kinetic proofreading of chromatin remodeling from gene activation to gene repression and back |
| topic | chromatin histone code remodeler bromodomain nucleosome histone |
| url | http://www.aimspress.com/biophysics/article/407/fulltext.html |
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