Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2020-03-01
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| Series: | Iranian Journal of Colorectal Research |
| Subjects: | |
| Online Access: | https://colorectalresearch.sums.ac.ir/article_46538_1e80213e37224b3916d6264810d9b07f.pdf |
| _version_ | 1811181661368352768 |
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| author | Morvarid Siri Seyed Vahid Hosseini Sanaz Dastghaib Pooneh Mokarram |
| author_facet | Morvarid Siri Seyed Vahid Hosseini Sanaz Dastghaib Pooneh Mokarram |
| author_sort | Morvarid Siri |
| collection | DOAJ |
| description | Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors. 3. Results Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions. 4. Conclusions The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways. |
| first_indexed | 2024-04-11T09:21:23Z |
| format | Article |
| id | doaj.art-528b21c058b244bf89ed4213525b77ec |
| institution | Directory Open Access Journal |
| issn | 2783-2430 |
| language | English |
| last_indexed | 2024-04-11T09:21:23Z |
| publishDate | 2020-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Colorectal Research |
| spelling | doaj.art-528b21c058b244bf89ed4213525b77ec2022-12-22T04:32:10ZengShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24302020-03-018191610.30476/acrr.2020.4653846538Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in CancerMorvarid Siri0Seyed Vahid Hosseini1Sanaz Dastghaib2Pooneh Mokarram3Department of biochemistry, Shiraz University of medical sciences, Shiraz, IranColorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of biochemistry, Shiraz University of medical sciences, Shiraz, IranAutophagy Research center, Shiraz University of Medical Sciences, shiraz, Iran.Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors. 3. Results Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions. 4. Conclusions The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.https://colorectalresearch.sums.ac.ir/article_46538_1e80213e37224b3916d6264810d9b07f.pdfendoplasmic reticulumstresscanceruprwnt |
| spellingShingle | Morvarid Siri Seyed Vahid Hosseini Sanaz Dastghaib Pooneh Mokarram Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer Iranian Journal of Colorectal Research endoplasmic reticulum stress cancer upr wnt |
| title | Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer |
| title_full | Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer |
| title_fullStr | Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer |
| title_full_unstemmed | Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer |
| title_short | Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer |
| title_sort | crosstalk between er stress unfolded protein response upr and wnt signaling pathway in cancer |
| topic | endoplasmic reticulum stress cancer upr wnt |
| url | https://colorectalresearch.sums.ac.ir/article_46538_1e80213e37224b3916d6264810d9b07f.pdf |
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