Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction
The paper presents a model for predicting the protective efficacy of hormone replacement therapy (HRT) on the basis of a comprehensive evaluation of mineral density and metabolic activity of bone tissue. A positive correlation between the ratio of the differential rates of accumulation, representing...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2015-08-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/28433/pdf |
| _version_ | 1818752418337259520 |
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| author | I S Zakharov G I Kolpinskiy G A Ushakova |
| author_facet | I S Zakharov G I Kolpinskiy G A Ushakova |
| author_sort | I S Zakharov |
| collection | DOAJ |
| description | The paper presents a model for predicting the protective efficacy of hormone replacement therapy (HRT) on the basis of a comprehensive evaluation of mineral density and metabolic activity of bone tissue. A positive correlation between the ratio of the differential rates of accumulation, representing the ratio between the standardized rates of accumulation of the lumbar vertebrae and femoral neck, and increase bone mineral density (BMD) of the lumbar vertebrae (L2-L4) using HRT. Determined inverse relationship between the initial level of the BMD and its growth against the backdrop of 12 months of use of HRT drugs. Established predictive model will allow a reasonably prescribe HRT that will enhance the efficiency of correction postmenopausal osteoporotic changes and reduce the side effects associated with the use of this group of drugs. |
| first_indexed | 2024-12-18T04:51:09Z |
| format | Article |
| id | doaj.art-528b4f8d3b5e402c84f88508335873ff |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-12-18T04:51:09Z |
| publishDate | 2015-08-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-528b4f8d3b5e402c84f88508335873ff2022-12-21T21:20:24ZrusIP Berlin A.V.Гинекология2079-56962079-58312015-08-01174161825562Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correctionI S Zakharov0G I Kolpinskiy1G A Ushakova2Kemerovo State Medical Academy of the Ministry of Health of the Russian FederationKemerovo State Medical Academy of the Ministry of Health of the Russian FederationKemerovo State Medical Academy of the Ministry of Health of the Russian FederationThe paper presents a model for predicting the protective efficacy of hormone replacement therapy (HRT) on the basis of a comprehensive evaluation of mineral density and metabolic activity of bone tissue. A positive correlation between the ratio of the differential rates of accumulation, representing the ratio between the standardized rates of accumulation of the lumbar vertebrae and femoral neck, and increase bone mineral density (BMD) of the lumbar vertebrae (L2-L4) using HRT. Determined inverse relationship between the initial level of the BMD and its growth against the backdrop of 12 months of use of HRT drugs. Established predictive model will allow a reasonably prescribe HRT that will enhance the efficiency of correction postmenopausal osteoporotic changes and reduce the side effects associated with the use of this group of drugs.https://gynecology.orscience.ru/2079-5831/article/viewFile/28433/pdfpostmenopausal osteoporosisbone mineral densityhormone replacement therapyprognosis |
| spellingShingle | I S Zakharov G I Kolpinskiy G A Ushakova Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction Гинекология postmenopausal osteoporosis bone mineral density hormone replacement therapy prognosis |
| title | Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction |
| title_full | Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction |
| title_fullStr | Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction |
| title_full_unstemmed | Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction |
| title_short | Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction |
| title_sort | predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction |
| topic | postmenopausal osteoporosis bone mineral density hormone replacement therapy prognosis |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/28433/pdf |
| work_keys_str_mv | AT iszakharov predictingtheeffectivenessofhormonereplacementtherapyinpostmenopausalosteoporoticchangescorrection AT gikolpinskiy predictingtheeffectivenessofhormonereplacementtherapyinpostmenopausalosteoporoticchangescorrection AT gaushakova predictingtheeffectivenessofhormonereplacementtherapyinpostmenopausalosteoporoticchangescorrection |