Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes
Sporotrichosis is the most frequent subcutaneous or implantation mycosis in Latin America, and its transmission occurs as a result of traumatic inoculation into the skin by organic matter containing the thermodimorphic fungi of the genus <i>Sporothrix</i>. Although cutaneous forms are mo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/10/956 |
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| author | Bruno Ivanovinsky Costa de Sousa Livia Cristina Fonseca Ferreira Marcella Morgado Ramiro de Lima Juliana dos Santos Barbosa Netto Guis Saint-Martin Astacio Andréa Reis Bernardes-Engemann Priscila Marques de Macedo Maria Clara Gutierrez-Galhardo Dayvison Francis Saraiva Freitas |
| author_facet | Bruno Ivanovinsky Costa de Sousa Livia Cristina Fonseca Ferreira Marcella Morgado Ramiro de Lima Juliana dos Santos Barbosa Netto Guis Saint-Martin Astacio Andréa Reis Bernardes-Engemann Priscila Marques de Macedo Maria Clara Gutierrez-Galhardo Dayvison Francis Saraiva Freitas |
| author_sort | Bruno Ivanovinsky Costa de Sousa |
| collection | DOAJ |
| description | Sporotrichosis is the most frequent subcutaneous or implantation mycosis in Latin America, and its transmission occurs as a result of traumatic inoculation into the skin by organic matter containing the thermodimorphic fungi of the genus <i>Sporothrix</i>. Although cutaneous forms are more common, another important site is the osteoarticular system, whose hematogenous involvement is commonly associated with disseminated forms, especially in people who have an immunosuppressive condition, such as HIV/AIDS, chronic steroid use, and alcohol abuse. We present two cases of osteoarticular sporotrichosis of the knee caused by <i>Sporothrix brasiliensis</i> and followed up at our institution, with different outcomes. In the cases presented here, aging, anatomical sites, comorbidities, subtherapeutic serum levels, low adherence to treatment, and late diagnosis for different reasons may explain the observed outcomes. Early diagnosis of <i>Sporothrix</i> infection is critical in preventing complications, including death. We also highlight the importance of multidisciplinary follow-up and adherence to treatment for a favorable outcome. |
| first_indexed | 2024-03-10T21:07:49Z |
| format | Article |
| id | doaj.art-528b6716631a4589a49a06b8106223f8 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T21:07:49Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-528b6716631a4589a49a06b8106223f82023-11-19T17:00:12ZengMDPI AGJournal of Fungi2309-608X2023-09-0191095610.3390/jof9100956Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different OutcomesBruno Ivanovinsky Costa de Sousa0Livia Cristina Fonseca Ferreira1Marcella Morgado Ramiro de Lima2Juliana dos Santos Barbosa Netto3Guis Saint-Martin Astacio4Andréa Reis Bernardes-Engemann5Priscila Marques de Macedo6Maria Clara Gutierrez-Galhardo7Dayvison Francis Saraiva Freitas8Vice-Direção de Ensino, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilVice-Direção de Ensino, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilVice-Direção de Ensino, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilLaboratório de Pesquisa Clínica em DST/AIDS, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilServiço de Imagem, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilLaboratório de Pesquisa Clínica em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilLaboratório de Pesquisa Clínica em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilLaboratório de Pesquisa Clínica em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, BrazilSporotrichosis is the most frequent subcutaneous or implantation mycosis in Latin America, and its transmission occurs as a result of traumatic inoculation into the skin by organic matter containing the thermodimorphic fungi of the genus <i>Sporothrix</i>. Although cutaneous forms are more common, another important site is the osteoarticular system, whose hematogenous involvement is commonly associated with disseminated forms, especially in people who have an immunosuppressive condition, such as HIV/AIDS, chronic steroid use, and alcohol abuse. We present two cases of osteoarticular sporotrichosis of the knee caused by <i>Sporothrix brasiliensis</i> and followed up at our institution, with different outcomes. In the cases presented here, aging, anatomical sites, comorbidities, subtherapeutic serum levels, low adherence to treatment, and late diagnosis for different reasons may explain the observed outcomes. Early diagnosis of <i>Sporothrix</i> infection is critical in preventing complications, including death. We also highlight the importance of multidisciplinary follow-up and adherence to treatment for a favorable outcome.https://www.mdpi.com/2309-608X/9/10/956sporotrichosis<i>Sporothrix brasiliensis</i>osteoarticularamphotericin Bitraconazole |
| spellingShingle | Bruno Ivanovinsky Costa de Sousa Livia Cristina Fonseca Ferreira Marcella Morgado Ramiro de Lima Juliana dos Santos Barbosa Netto Guis Saint-Martin Astacio Andréa Reis Bernardes-Engemann Priscila Marques de Macedo Maria Clara Gutierrez-Galhardo Dayvison Francis Saraiva Freitas Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes Journal of Fungi sporotrichosis <i>Sporothrix brasiliensis</i> osteoarticular amphotericin B itraconazole |
| title | Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes |
| title_full | Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes |
| title_fullStr | Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes |
| title_full_unstemmed | Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes |
| title_short | Osteoarticular Sporotrichosis of the Knee Caused by <i>Sporothrix brasiliensis</i>: Two Similar Cases with Different Outcomes |
| title_sort | osteoarticular sporotrichosis of the knee caused by i sporothrix brasiliensis i two similar cases with different outcomes |
| topic | sporotrichosis <i>Sporothrix brasiliensis</i> osteoarticular amphotericin B itraconazole |
| url | https://www.mdpi.com/2309-608X/9/10/956 |
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