Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience
Background: Excess bodyweight is known to influence the risk of colorectal cancer; however, little evidence exists for the influence of the body mass index (BMI) on the long-term outcome of patients with rectal cancer. Methods: We assessed the impact of the BMI on the risk of local recurrence, dista...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-04-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/5/609 |
| _version_ | 1797763558032801792 |
|---|---|
| author | Maximilian Kalb Melanie C. Langheinrich Susanne Merkel Christian Krautz Maximilian Brunner Alan Bénard Klaus Weber Christian Pilarsky Robert Grützmann Georg F. Weber |
| author_facet | Maximilian Kalb Melanie C. Langheinrich Susanne Merkel Christian Krautz Maximilian Brunner Alan Bénard Klaus Weber Christian Pilarsky Robert Grützmann Georg F. Weber |
| author_sort | Maximilian Kalb |
| collection | DOAJ |
| description | Background: Excess bodyweight is known to influence the risk of colorectal cancer; however, little evidence exists for the influence of the body mass index (BMI) on the long-term outcome of patients with rectal cancer. Methods: We assessed the impact of the BMI on the risk of local recurrence, distant metastasis and overall—survival in 612 patients between 2003 and 2010 after rectal cancer diagnosis and treatment at the University Hospital Erlangen. A Cox-regression model was used to estimate the hazard ratio and multivariate risk of mortality and distant-metastasis. Median follow up-time was 58 months. Results: Patients with obesity class II or higher (BMI ≥ 35 kg/m<sup>2</sup>, <i>n</i> = 25) and patients with underweight (BMI < 18.5 kg/m<sup>2</sup>, <i>n</i> = 5) had reduced overall survival (hazard ratio (HR) = 1.6; 95% confidence interval (CI) 0.9−2.7) as well as higher rates of distant metastases (hazard ratio HR = 1.7; 95% CI 0.9−3.3) as compared to patients with normal bodyweight (18.5 ≤ BMI < 25 kg/m<sup>2</sup>, <i>n</i> = 209), overweight (25 ≤ BMI <30 kg/m<sup>2</sup>, <i>n</i> = 257) or obesity class I (30 ≤ BMI <35 kg/m<sup>2</sup>, <i>n</i> = 102). There were no significant differences for local recurrence. Conclusions: Underweight and excess bodyweight are associated with lower overall survival and higher rates of distant metastasis in patients with rectal cancer. |
| first_indexed | 2024-03-12T19:43:11Z |
| format | Article |
| id | doaj.art-528c49feb5224d6f8bb68a9a453dda8c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:43:11Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-528c49feb5224d6f8bb68a9a453dda8c2023-08-02T03:41:47ZengMDPI AGCancers2072-66942019-04-0111560910.3390/cancers11050609cancers11050609Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre ExperienceMaximilian Kalb0Melanie C. Langheinrich1Susanne Merkel2Christian Krautz3Maximilian Brunner4Alan Bénard5Klaus Weber6Christian Pilarsky7Robert Grützmann8Georg F. Weber9Department of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyDepartment of Surgery, Erlangen University Hospital, Krankenhausstraße 12, 91054 Erlangen, GermanyBackground: Excess bodyweight is known to influence the risk of colorectal cancer; however, little evidence exists for the influence of the body mass index (BMI) on the long-term outcome of patients with rectal cancer. Methods: We assessed the impact of the BMI on the risk of local recurrence, distant metastasis and overall—survival in 612 patients between 2003 and 2010 after rectal cancer diagnosis and treatment at the University Hospital Erlangen. A Cox-regression model was used to estimate the hazard ratio and multivariate risk of mortality and distant-metastasis. Median follow up-time was 58 months. Results: Patients with obesity class II or higher (BMI ≥ 35 kg/m<sup>2</sup>, <i>n</i> = 25) and patients with underweight (BMI < 18.5 kg/m<sup>2</sup>, <i>n</i> = 5) had reduced overall survival (hazard ratio (HR) = 1.6; 95% confidence interval (CI) 0.9−2.7) as well as higher rates of distant metastases (hazard ratio HR = 1.7; 95% CI 0.9−3.3) as compared to patients with normal bodyweight (18.5 ≤ BMI < 25 kg/m<sup>2</sup>, <i>n</i> = 209), overweight (25 ≤ BMI <30 kg/m<sup>2</sup>, <i>n</i> = 257) or obesity class I (30 ≤ BMI <35 kg/m<sup>2</sup>, <i>n</i> = 102). There were no significant differences for local recurrence. Conclusions: Underweight and excess bodyweight are associated with lower overall survival and higher rates of distant metastasis in patients with rectal cancer.https://www.mdpi.com/2072-6694/11/5/609body mass indexrectal canceroverall survivaldistant metastasis |
| spellingShingle | Maximilian Kalb Melanie C. Langheinrich Susanne Merkel Christian Krautz Maximilian Brunner Alan Bénard Klaus Weber Christian Pilarsky Robert Grützmann Georg F. Weber Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience Cancers body mass index rectal cancer overall survival distant metastasis |
| title | Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience |
| title_full | Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience |
| title_fullStr | Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience |
| title_full_unstemmed | Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience |
| title_short | Influence of Body Mass Index on Long-Term Outcome in Patients with Rectal Cancer—A Single Centre Experience |
| title_sort | influence of body mass index on long term outcome in patients with rectal cancer a single centre experience |
| topic | body mass index rectal cancer overall survival distant metastasis |
| url | https://www.mdpi.com/2072-6694/11/5/609 |
| work_keys_str_mv | AT maximiliankalb influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT melanieclangheinrich influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT susannemerkel influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT christiankrautz influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT maximilianbrunner influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT alanbenard influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT klausweber influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT christianpilarsky influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT robertgrutzmann influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience AT georgfweber influenceofbodymassindexonlongtermoutcomeinpatientswithrectalcancerasinglecentreexperience |