Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral?
Abstract Neurodegenerative dementias such as the behavioral variant of frontotemporal dementia, Alzheimer’s disease, and Parkinson’s disease dementia are linked to various behavioral and psychological abnormalities. Whether these abnormalities precede, coincide or follow the onset of cognitive sympt...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-09-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-022-00538-x |
| _version_ | 1798004428218826752 |
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| author | Souvik Dubey Mahua Jana Dubey Ritwik Ghosh Debaleena Mukherjee Alak Pandit Julian Benito-León |
| author_facet | Souvik Dubey Mahua Jana Dubey Ritwik Ghosh Debaleena Mukherjee Alak Pandit Julian Benito-León |
| author_sort | Souvik Dubey |
| collection | DOAJ |
| description | Abstract Neurodegenerative dementias such as the behavioral variant of frontotemporal dementia, Alzheimer’s disease, and Parkinson’s disease dementia are linked to various behavioral and psychological abnormalities. Whether these abnormalities precede, coincide or follow the onset of cognitive symptoms is still controversial in existing literature, with trajectories available so far dependent on types of dementia. The authors aim to review the different kinds of premorbid behavioral symptoms/personality traits associated with an increased risk of developing specific types of neurodegenerative dementia. Neuroticism has been associated with an increased risk of Alzheimer’s disease and late-onset behavioral abnormalities with the behavioral variant of frontotemporal dementia. The presence of obsessive–compulsive spectrum disorders in Parkinson’s disease dementia is also not rare. Analyzing this evidence, we propose “behavioral biomarkers” as neuroticism in Alzheimer’s disease, late-onset behavioral abnormalities in behavioral variant of frontotemporal dementia, and obsessive–compulsive traits in Parkinson’s disease dementia. These noninvasive behavioral biomarkers will be of immense help, particularly in developing countries, and will prevent the need for costlier investigations and aid in therapeutic strategies. |
| first_indexed | 2024-04-11T12:23:32Z |
| format | Article |
| id | doaj.art-528c74500f38427db26fb2520103d9ce |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-11T12:23:32Z |
| publishDate | 2022-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-528c74500f38427db26fb2520103d9ce2022-12-22T04:24:01ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292022-09-015811610.1186/s41983-022-00538-xBehavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral?Souvik Dubey0Mahua Jana Dubey1Ritwik Ghosh2Debaleena Mukherjee3Alak Pandit4Julian Benito-León5Department of Neuromedicine, Bangur Institute of NeurosciencesDepartment of Psychiatry, Berhampore Mental HospitalDepartment of General Medicine, Burdwan Medical College, and HospitalDepartment of Neuromedicine, Bangur Institute of NeurosciencesDepartment of Neuromedicine, Bangur Institute of NeurosciencesDepartment of Neurology, University Hospital “12 de Octubre”Abstract Neurodegenerative dementias such as the behavioral variant of frontotemporal dementia, Alzheimer’s disease, and Parkinson’s disease dementia are linked to various behavioral and psychological abnormalities. Whether these abnormalities precede, coincide or follow the onset of cognitive symptoms is still controversial in existing literature, with trajectories available so far dependent on types of dementia. The authors aim to review the different kinds of premorbid behavioral symptoms/personality traits associated with an increased risk of developing specific types of neurodegenerative dementia. Neuroticism has been associated with an increased risk of Alzheimer’s disease and late-onset behavioral abnormalities with the behavioral variant of frontotemporal dementia. The presence of obsessive–compulsive spectrum disorders in Parkinson’s disease dementia is also not rare. Analyzing this evidence, we propose “behavioral biomarkers” as neuroticism in Alzheimer’s disease, late-onset behavioral abnormalities in behavioral variant of frontotemporal dementia, and obsessive–compulsive traits in Parkinson’s disease dementia. These noninvasive behavioral biomarkers will be of immense help, particularly in developing countries, and will prevent the need for costlier investigations and aid in therapeutic strategies.https://doi.org/10.1186/s41983-022-00538-xBehavioral symptomsDementiaNeuroticismObsessive-compulsive disordersLate-onset behavioral abnormalitiesPersonality traits |
| spellingShingle | Souvik Dubey Mahua Jana Dubey Ritwik Ghosh Debaleena Mukherjee Alak Pandit Julian Benito-León Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral? The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Behavioral symptoms Dementia Neuroticism Obsessive-compulsive disorders Late-onset behavioral abnormalities Personality traits |
| title | Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral? |
| title_full | Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral? |
| title_fullStr | Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral? |
| title_full_unstemmed | Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral? |
| title_short | Behavioral and psychological symptoms in neurodegenerative dementias: harbinger, follower, or constant collateral? |
| title_sort | behavioral and psychological symptoms in neurodegenerative dementias harbinger follower or constant collateral |
| topic | Behavioral symptoms Dementia Neuroticism Obsessive-compulsive disorders Late-onset behavioral abnormalities Personality traits |
| url | https://doi.org/10.1186/s41983-022-00538-x |
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