Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease
There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chron...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2011-11-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3826 |
| _version_ | 1818531413841936384 |
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| author | Seyyed Hamid Hashemi Ebrahim Nadi Mehrdad Hajilooi Mohammad-Ali Seif-Rabiei Uldoz Roustaei |
| author_facet | Seyyed Hamid Hashemi Ebrahim Nadi Mehrdad Hajilooi Mohammad-Ali Seif-Rabiei Uldoz Roustaei |
| author_sort | Seyyed Hamid Hashemi |
| collection | DOAJ |
| description | There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chronic obstructive pulmonary disease (COPD). In a case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-H. pylori and anti-CagA IgG by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history, and spirometric findings for each patient. Of 90 patients with COPD 66 (51%) had mild, 31 (34.4%) moderate, and 13 (14.4%) sever disease. There was no significant association between H. pylori IgG seropositivity and COPD. Serum levels of anti-CagA IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between H. pylori infection and severity of COPD. The results suggest that there is an association between CagA-positive H. pylori infections and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms that might underlie these associations. |
| first_indexed | 2024-12-11T17:32:09Z |
| format | Article |
| id | doaj.art-528de60e726e4cf9a3863109c3e86858 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-11T17:32:09Z |
| publishDate | 2011-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-528de60e726e4cf9a3863109c3e868582022-12-22T00:56:46ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942011-11-014911Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary DiseaseSeyyed Hamid Hashemi0Ebrahim Nadi1Mehrdad Hajilooi2Mohammad-Ali Seif-Rabiei3Uldoz Roustaei4Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, Iran.Department of Pulmonary Diseases, Hamedan University of Medical Sciences, Hamedan, Iran.Department of Immunology, Hamedan University of Medical Sciences, Hamedan, Iran.Department of Social Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, Iran.There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chronic obstructive pulmonary disease (COPD). In a case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-H. pylori and anti-CagA IgG by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history, and spirometric findings for each patient. Of 90 patients with COPD 66 (51%) had mild, 31 (34.4%) moderate, and 13 (14.4%) sever disease. There was no significant association between H. pylori IgG seropositivity and COPD. Serum levels of anti-CagA IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between H. pylori infection and severity of COPD. The results suggest that there is an association between CagA-positive H. pylori infections and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms that might underlie these associations.https://acta.tums.ac.ir/index.php/acta/article/view/3826COPDHelicobacter pyloriInfection |
| spellingShingle | Seyyed Hamid Hashemi Ebrahim Nadi Mehrdad Hajilooi Mohammad-Ali Seif-Rabiei Uldoz Roustaei Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease Acta Medica Iranica COPD Helicobacter pylori Infection |
| title | Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease |
| title_full | Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease |
| title_fullStr | Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease |
| title_short | Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease |
| title_sort | relationship between helicobacter pylori infection and chronic obstructive pulmonary disease |
| topic | COPD Helicobacter pylori Infection |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3826 |
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