Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients
Abstract Background Specific clinical risk factors may contribute to improving or worsening neurological functions in acute ischemic stroke (AIS) patients pre-treated with a combined cholesterol reducer and recombinant tissue plasminogen activator (rtPA) therapy. In this study, clinical risk factors...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-020-01270-2 |
| _version_ | 1831761333038612480 |
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| author | Nicolas Poupore Dan Strat Tristan Mackey Katherine Brown Ashley Snell Thomas I. Nathaniel |
| author_facet | Nicolas Poupore Dan Strat Tristan Mackey Katherine Brown Ashley Snell Thomas I. Nathaniel |
| author_sort | Nicolas Poupore |
| collection | DOAJ |
| description | Abstract Background Specific clinical risk factors may contribute to improving or worsening neurological functions in acute ischemic stroke (AIS) patients pre-treated with a combined cholesterol reducer and recombinant tissue plasminogen activator (rtPA) therapy. In this study, clinical risk factors associated with good or poor presenting neurological symptoms in ischemic stroke patients with prior cholesterol reducer use, specifically a statin and rtPA therapy was investigated. Methods Retrospective data for baseline clinical and demographic data for patients with AIS taking cholesterol reducers prior to rtPA treatment from January 2010 to June 2016 in a regional stroke center was analyzed. Improving (NIHSS score ≤ 7) or worsening (NIHSS score > 7) of neurologic functions were the determined measures of treatment outcome. Multivariate logistic regression models identified demographic and clinical factors associated with worsening or improving neurologic functions. Results Adjusted multivariate analysis showed that in an AIS population with a combined rtPA and cholesterol reducer medication history, increasing age (OR = 1.032, 95% CI, 1.015–1.048, P < 0.001) and atrial fibrillation (OR = 1.859, 95% CI, 1.098–3.149, P = 0.021) demonstrated a likely association with worsening neurologic functions, while direct admission (OR = 0.411, 95% CI, 0.246–0.686, P = 0.001) and being Caucasian (OR = 0.496, 95% CI, 0.297–0.827, P = 0.007) showed an association with improving or progressing neurologic functions. Conclusion A prior cholesterol reducer, namely a statin, plus rtPA combination may be associated with worsening neurological function for elderly AIS patients with atrial fibrillation, while Caucasians directly admitted to a neurology unit are more likely to show an association with progress or improvements in neurologic functions. While combining statin with rtPA treatment may facilitate worsening neurologic functions in elderly AIS patients with atrial fibrillation, they should not be denied of this therapy. The decision to combine statin and rtPA for AIS patients with atrial fibrillation can be done after clinical stabilization following appropriate clinical management. |
| first_indexed | 2024-12-22T04:46:50Z |
| format | Article |
| id | doaj.art-528e5bf663204fa992dd67637baefa9d |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-22T04:46:50Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-528e5bf663204fa992dd67637baefa9d2022-12-21T18:38:36ZengBMCLipids in Health and Disease1476-511X2020-05-0119111410.1186/s12944-020-01270-2Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patientsNicolas Poupore0Dan Strat1Tristan Mackey2Katherine Brown3Ashley Snell4Thomas I. Nathaniel5University of South Carolina School of Medicine GreenvilleUniversity of South Carolina School of Medicine GreenvilleUniversity of South Carolina School of Medicine GreenvilleUniversity of South Carolina School of Medicine GreenvilleUniversity of South Carolina School of Medicine GreenvilleUniversity of South Carolina School of Medicine GreenvilleAbstract Background Specific clinical risk factors may contribute to improving or worsening neurological functions in acute ischemic stroke (AIS) patients pre-treated with a combined cholesterol reducer and recombinant tissue plasminogen activator (rtPA) therapy. In this study, clinical risk factors associated with good or poor presenting neurological symptoms in ischemic stroke patients with prior cholesterol reducer use, specifically a statin and rtPA therapy was investigated. Methods Retrospective data for baseline clinical and demographic data for patients with AIS taking cholesterol reducers prior to rtPA treatment from January 2010 to June 2016 in a regional stroke center was analyzed. Improving (NIHSS score ≤ 7) or worsening (NIHSS score > 7) of neurologic functions were the determined measures of treatment outcome. Multivariate logistic regression models identified demographic and clinical factors associated with worsening or improving neurologic functions. Results Adjusted multivariate analysis showed that in an AIS population with a combined rtPA and cholesterol reducer medication history, increasing age (OR = 1.032, 95% CI, 1.015–1.048, P < 0.001) and atrial fibrillation (OR = 1.859, 95% CI, 1.098–3.149, P = 0.021) demonstrated a likely association with worsening neurologic functions, while direct admission (OR = 0.411, 95% CI, 0.246–0.686, P = 0.001) and being Caucasian (OR = 0.496, 95% CI, 0.297–0.827, P = 0.007) showed an association with improving or progressing neurologic functions. Conclusion A prior cholesterol reducer, namely a statin, plus rtPA combination may be associated with worsening neurological function for elderly AIS patients with atrial fibrillation, while Caucasians directly admitted to a neurology unit are more likely to show an association with progress or improvements in neurologic functions. While combining statin with rtPA treatment may facilitate worsening neurologic functions in elderly AIS patients with atrial fibrillation, they should not be denied of this therapy. The decision to combine statin and rtPA for AIS patients with atrial fibrillation can be done after clinical stabilization following appropriate clinical management.http://link.springer.com/article/10.1186/s12944-020-01270-2Cholesterol reducerNIHSS scoreNeurological deficitsThrombolytic therapyIschemic stroke |
| spellingShingle | Nicolas Poupore Dan Strat Tristan Mackey Katherine Brown Ashley Snell Thomas I. Nathaniel Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients Lipids in Health and Disease Cholesterol reducer NIHSS score Neurological deficits Thrombolytic therapy Ischemic stroke |
| title | Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients |
| title_full | Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients |
| title_fullStr | Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients |
| title_full_unstemmed | Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients |
| title_short | Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients |
| title_sort | cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients |
| topic | Cholesterol reducer NIHSS score Neurological deficits Thrombolytic therapy Ischemic stroke |
| url | http://link.springer.com/article/10.1186/s12944-020-01270-2 |
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