Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil
Antecedents of familial aggregation of breast and ovarian cancer are observed in only 5-8% of all breast cancer cases. Nevertheless, this variable displays one of the highest risk ratios associated to breast cancer outcome. Despite recent identification of genetic mutations associated with familial...
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| Format: | Article |
| Language: | English |
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
1998-01-01
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| Series: | Cadernos de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700019 |
| _version_ | 1811344987549335552 |
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| author | Koifman Rosalina Jorge Koifman Sergio Vieira Roberto José da Silva |
| author_facet | Koifman Rosalina Jorge Koifman Sergio Vieira Roberto José da Silva |
| author_sort | Koifman Rosalina Jorge |
| collection | DOAJ |
| description | Antecedents of familial aggregation of breast and ovarian cancer are observed in only 5-8% of all breast cancer cases. Nevertheless, this variable displays one of the highest risk ratios associated to breast cancer outcome. Despite recent identification of genetic mutations associated with familial aggregation of these tumors, mainly at BRCA1 and BRCA2 genes, knowledge on the interaction between environmental agents in these families remains quite unclear. In this paper we ascertained the correlation among ages of the onset of breast/ovarian cancer in 260 Brazilian families with those cancer aggregation. Further we estimated the median age of the onset of breast cancer among four generations. We observed that the higher the number of family cancer cases, the highest is the correlation of ages for the onset of breast cancer. We also observed a 8-10 year decline in the mean age-of-onset of breast/ovarian cancer from one generation to another in the studied families. If these results could be confirmed elsewhere, we believe that the hypothesis of interaction between environmental risks factors in families indeed showing breast/ovarian cancer aggregation is reinforced. |
| first_indexed | 2024-04-13T19:56:20Z |
| format | Article |
| id | doaj.art-528ea0249c30428e867fcc05331ae11c |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-04-13T19:56:20Z |
| publishDate | 1998-01-01 |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-528ea0249c30428e867fcc05331ae11c2022-12-22T02:32:20ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44641998-01-0114suppl.3181185Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in BrazilKoifman Rosalina JorgeKoifman SergioVieira Roberto José da SilvaAntecedents of familial aggregation of breast and ovarian cancer are observed in only 5-8% of all breast cancer cases. Nevertheless, this variable displays one of the highest risk ratios associated to breast cancer outcome. Despite recent identification of genetic mutations associated with familial aggregation of these tumors, mainly at BRCA1 and BRCA2 genes, knowledge on the interaction between environmental agents in these families remains quite unclear. In this paper we ascertained the correlation among ages of the onset of breast/ovarian cancer in 260 Brazilian families with those cancer aggregation. Further we estimated the median age of the onset of breast cancer among four generations. We observed that the higher the number of family cancer cases, the highest is the correlation of ages for the onset of breast cancer. We also observed a 8-10 year decline in the mean age-of-onset of breast/ovarian cancer from one generation to another in the studied families. If these results could be confirmed elsewhere, we believe that the hypothesis of interaction between environmental risks factors in families indeed showing breast/ovarian cancer aggregation is reinforced.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700019NeoplasmBreastOvary/OvarianGenetics |
| spellingShingle | Koifman Rosalina Jorge Koifman Sergio Vieira Roberto José da Silva Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil Cadernos de Saúde Pública Neoplasm Breast Ovary/Ovarian Genetics |
| title | Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil |
| title_full | Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil |
| title_fullStr | Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil |
| title_full_unstemmed | Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil |
| title_short | Familial aggregation of breast/ovarian cancer: age of onset along subsequent generations in Brazil |
| title_sort | familial aggregation of breast ovarian cancer age of onset along subsequent generations in brazil |
| topic | Neoplasm Breast Ovary/Ovarian Genetics |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700019 |
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