Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies

Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies

Background and purpose: Aberrant signaling by oncogenic RAS proteins occurs in almost all human tumors. One of the promising strategies to overcome such cancers is the inhibition of KRAS protein, a subtype of RAS family involved in cell growth, differentiation, and apoptosis, through preventing its...

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Bibliographic Details
Main Authors: Samaneh Hashemi, Amirhossein Sharifi, Sara Zareei, Ghazale Mohamedi, Mahmood Biglar, Massoud Amanlou
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
auriculasin; docking studies; flavonoid; kras; molecular dynamic simulations; virtual screening
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=3;spage=226;epage=240;aulast=Hashemi

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=3;spage=226;epage=240;aulast=Hashemi

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