Advancing cancer theranostics through biomimetics: A comprehensive review
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by natu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402403723X |
| _version_ | 1827293980622061568 |
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| author | Kuttiappan Anitha Santenna Chenchula Vijayaraj Surendran Bhatt Shvetank Parameswar Ravula Rhythm Milan Radhika Chikatipalli Padmavathi R |
| author_facet | Kuttiappan Anitha Santenna Chenchula Vijayaraj Surendran Bhatt Shvetank Parameswar Ravula Rhythm Milan Radhika Chikatipalli Padmavathi R |
| author_sort | Kuttiappan Anitha |
| collection | DOAJ |
| description | Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers. Biomimetic approaches have been explored to address multidrug resistance (MDR), emphasizing their role in immunotherapy and photothermal therapy. The specific areas covered include biomimetic drug delivery systems bypassing MDR mechanisms, biomimetic platforms for immune checkpoint blockade, immune cell modulation, and photothermal tumor ablation. Pretargeting techniques enhancing radiotherapeutic agent uptake are discussed, along with a comprehensive review of clinical trials of global nanotheranostics. This review delves into biomimetic materials, nanotechnology, and bioinspired strategies for cancer imaging, diagnosis, and targeted drug delivery. These include imaging probes, contrast agents, and biosensors for enhanced specificity and sensitivity. Biomimetic strategies for targeted drug delivery involve the design of nanoparticles, liposomes, and hydrogels for site-specific delivery and improved therapeutic efficacy. Overall, this current review provides valuable information for investigators, clinicians, and biomedical engineers, offering insights into the latest biomimetics applications in cancer theranostics. Leveraging biomimetics aims to revolutionize cancer diagnosis, treatment, and patient outcomes. |
| first_indexed | 2024-04-24T13:49:17Z |
| format | Article |
| id | doaj.art-528f56041f124ded8bcc645012897c99 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:49:17Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-528f56041f124ded8bcc645012897c992024-04-04T05:05:35ZengElsevierHeliyon2405-84402024-03-01106e27692Advancing cancer theranostics through biomimetics: A comprehensive reviewKuttiappan Anitha0Santenna Chenchula1Vijayaraj Surendran2Bhatt Shvetank3Parameswar Ravula4Rhythm Milan5Radhika Chikatipalli6Padmavathi R7Department of Pharmacology, School of Pharmacy and Technology Management (SPTM), SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-University, Shirpur, 425405, IndiaDepartment of Clinical Pharmacology, All India Institute of Medical Sciences (AIIMS), Bhopal, 462020, Madhya Pradesh, India; Corresponding author.Dr Kalam College of Pharmacy, Thanjavur District, Tamil Nadu, 614 623, IndiaSchool of Health Sciences and Technology, Dr Vishwanath Karad MIT World Peace University, Pune, 411038, Maharashtra, IndiaAmity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior, 474005, Madhya Pradesh, IndiaAmity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior, 474005, Madhya Pradesh, IndiaSri Venkateshwara College of Pharmacy, Chittoor District, Andhra Pradesh, 517520, IndiaSVS Medical College, Mahbubnagar, Telangana, IndiaNanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers. Biomimetic approaches have been explored to address multidrug resistance (MDR), emphasizing their role in immunotherapy and photothermal therapy. The specific areas covered include biomimetic drug delivery systems bypassing MDR mechanisms, biomimetic platforms for immune checkpoint blockade, immune cell modulation, and photothermal tumor ablation. Pretargeting techniques enhancing radiotherapeutic agent uptake are discussed, along with a comprehensive review of clinical trials of global nanotheranostics. This review delves into biomimetic materials, nanotechnology, and bioinspired strategies for cancer imaging, diagnosis, and targeted drug delivery. These include imaging probes, contrast agents, and biosensors for enhanced specificity and sensitivity. Biomimetic strategies for targeted drug delivery involve the design of nanoparticles, liposomes, and hydrogels for site-specific delivery and improved therapeutic efficacy. Overall, this current review provides valuable information for investigators, clinicians, and biomedical engineers, offering insights into the latest biomimetics applications in cancer theranostics. Leveraging biomimetics aims to revolutionize cancer diagnosis, treatment, and patient outcomes.http://www.sciencedirect.com/science/article/pii/S240584402403723XTheranosticsBiomimeticsLung cancerBreast cancerSkin cancerGastric cancer |
| spellingShingle | Kuttiappan Anitha Santenna Chenchula Vijayaraj Surendran Bhatt Shvetank Parameswar Ravula Rhythm Milan Radhika Chikatipalli Padmavathi R Advancing cancer theranostics through biomimetics: A comprehensive review Heliyon Theranostics Biomimetics Lung cancer Breast cancer Skin cancer Gastric cancer |
| title | Advancing cancer theranostics through biomimetics: A comprehensive review |
| title_full | Advancing cancer theranostics through biomimetics: A comprehensive review |
| title_fullStr | Advancing cancer theranostics through biomimetics: A comprehensive review |
| title_full_unstemmed | Advancing cancer theranostics through biomimetics: A comprehensive review |
| title_short | Advancing cancer theranostics through biomimetics: A comprehensive review |
| title_sort | advancing cancer theranostics through biomimetics a comprehensive review |
| topic | Theranostics Biomimetics Lung cancer Breast cancer Skin cancer Gastric cancer |
| url | http://www.sciencedirect.com/science/article/pii/S240584402403723X |
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