Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective
Genetically modified plants (GMPs) intended for market release can be designed to induce “gene silencing” through RNA interference (RNAi). The European Food Safety Authority (EFSA) and other international risk assessment bodies/regulatory agencies have taken several actions to determine whether the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2020.00445/full |
| _version_ | 1818035748869242880 |
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| author | Nikoletta Papadopoulou Yann Devos Fernando Álvarez-Alfageme Anna Lanzoni Elisabeth Waigmann |
| author_facet | Nikoletta Papadopoulou Yann Devos Fernando Álvarez-Alfageme Anna Lanzoni Elisabeth Waigmann |
| author_sort | Nikoletta Papadopoulou |
| collection | DOAJ |
| description | Genetically modified plants (GMPs) intended for market release can be designed to induce “gene silencing” through RNA interference (RNAi). The European Food Safety Authority (EFSA) and other international risk assessment bodies/regulatory agencies have taken several actions to determine whether the existing risk assessment approaches for GMPs are appropriate for the risk assessment of RNAi-based GMPs or require complementary or alternative approaches. To our knowledge, at the international level, no dedicated guidelines have been developed for the risk assessment and regulation of RNAi-based GMPs, confirming that existing science-based risk assessment approaches for GMPs are generally considered suitable for RNAi-based GMPs. However, some specificities have been identified for the risk assessment of RNAi-based GMPs. Here, we report on some of these specificities as identified and addressed by the EFSA GMO Panel for the molecular characterisation, food/feed safety assessment and environmental risk assessment of RNAi-based GMPs, using the DvSnf7 dsRNA-expressing maize MON87411 as a case study. |
| first_indexed | 2024-12-10T06:59:59Z |
| format | Article |
| id | doaj.art-528f8bd4fecc47dfa30603a9dd2a5012 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-10T06:59:59Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-528f8bd4fecc47dfa30603a9dd2a50122022-12-22T01:58:21ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2020-04-011110.3389/fpls.2020.00445522254Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and PerspectiveNikoletta PapadopoulouYann DevosFernando Álvarez-AlfagemeAnna LanzoniElisabeth WaigmannGenetically modified plants (GMPs) intended for market release can be designed to induce “gene silencing” through RNA interference (RNAi). The European Food Safety Authority (EFSA) and other international risk assessment bodies/regulatory agencies have taken several actions to determine whether the existing risk assessment approaches for GMPs are appropriate for the risk assessment of RNAi-based GMPs or require complementary or alternative approaches. To our knowledge, at the international level, no dedicated guidelines have been developed for the risk assessment and regulation of RNAi-based GMPs, confirming that existing science-based risk assessment approaches for GMPs are generally considered suitable for RNAi-based GMPs. However, some specificities have been identified for the risk assessment of RNAi-based GMPs. Here, we report on some of these specificities as identified and addressed by the EFSA GMO Panel for the molecular characterisation, food/feed safety assessment and environmental risk assessment of RNAi-based GMPs, using the DvSnf7 dsRNA-expressing maize MON87411 as a case study.https://www.frontiersin.org/article/10.3389/fpls.2020.00445/fullcropsRNAidsRNADvSnf7gene silencingoff-target |
| spellingShingle | Nikoletta Papadopoulou Yann Devos Fernando Álvarez-Alfageme Anna Lanzoni Elisabeth Waigmann Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective Frontiers in Plant Science crops RNAi dsRNA DvSnf7 gene silencing off-target |
| title | Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective |
| title_full | Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective |
| title_fullStr | Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective |
| title_full_unstemmed | Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective |
| title_short | Risk Assessment Considerations for Genetically Modified RNAi Plants: EFSA’s Activities and Perspective |
| title_sort | risk assessment considerations for genetically modified rnai plants efsa s activities and perspective |
| topic | crops RNAi dsRNA DvSnf7 gene silencing off-target |
| url | https://www.frontiersin.org/article/10.3389/fpls.2020.00445/full |
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