NUDT15 and TPMT polymorphisms in three distinct native populations of the Brazilian Amazon

NUDT15 and TPMT polymorphisms in three distinct native populations of the Brazilian Amazon

This is the first report of the distribution of TPMT and NUDT15 single nucleotide polymorphisms and metabolic phenotypes associated with cytotoxicity of thiopurine drugs, in indigenous groups of Brazilian Amazon: Munduruku, Paiter-Suruí and Yanomami. The minor allele frequency (MAF) of NUDT15 rs1168...

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Bibliographic Details
Main Authors: Jamila Alessandra Perini, Paulo Cesar Basta, Guilherme Suarez-Kurtz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
Brazilian Amazon
native ancestry
population diversity
genetic polymorphism
NUDT15
TPMT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1359570/full

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