Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome
CD4+ T cells are prominent effector cells in controlling Mycobacterium tuberculosis (Mtb) infection but may also contribute to immunopathology. Studies probing the CD4+ T cell response from individuals latently infected with Mtb or patients with active tuberculosis using either small or proteome-wid...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00361/full |
| _version_ | 1818154441663053824 |
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| author | Cecile A.C.M. Van Els Veronique eCorbiere Kaat eSmits Jacqueline A.M. van Gaans-van den Brink Martien C.M. Poelen Francoise eMascart Francoise eMascart Hugo D. Meiring Camille eLocht Camille eLocht Camille eLocht Camille eLocht |
| author_facet | Cecile A.C.M. Van Els Veronique eCorbiere Kaat eSmits Jacqueline A.M. van Gaans-van den Brink Martien C.M. Poelen Francoise eMascart Francoise eMascart Hugo D. Meiring Camille eLocht Camille eLocht Camille eLocht Camille eLocht |
| author_sort | Cecile A.C.M. Van Els |
| collection | DOAJ |
| description | CD4+ T cells are prominent effector cells in controlling Mycobacterium tuberculosis (Mtb) infection but may also contribute to immunopathology. Studies probing the CD4+ T cell response from individuals latently infected with Mtb or patients with active tuberculosis using either small or proteome-wide antigen screens so far revealed a multi-antigenic, yet mostly invariable repertoire of immunogenic Mtb proteins. Recent developments in mass spectrometry-based proteomics have highlighted the occurrence of numerous types of post-translational modifications (PTM) in proteomes of prokaryotes, including Mtb. Well known PTMs in Mtb are glycosylation, lipidation or phosphorylation, known regulators of protein function or compartmentalization. Other PTM include methylation, acetylation and pupylation, involved in protein stability. While all PTM add variability to the Mtb proteome, relatively little is understood about their role in the anti-Mtb immune responses. Here, we review Mtb protein PTMs and methods to assess their role in protective immunity against Mtb. |
| first_indexed | 2024-12-11T14:26:34Z |
| format | Article |
| id | doaj.art-529431a55e594a109762739bb7945c67 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T14:26:34Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-529431a55e594a109762739bb7945c672022-12-22T01:02:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-08-01510.3389/fimmu.2014.0036193425Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteomeCecile A.C.M. Van Els0Veronique eCorbiere1Kaat eSmits2Jacqueline A.M. van Gaans-van den Brink3Martien C.M. Poelen4Francoise eMascart5Francoise eMascart6Hugo D. Meiring7Camille eLocht8Camille eLocht9Camille eLocht10Camille eLocht11National Institute for Public Health and the Environment (RIVM)Université Libre de Bruxelles (U.L.B.)Université Libre de Bruxelles (U.L.B.)National Institute for Public Health and the Environment (RIVM)National Institute for Public Health and the Environment (RIVM)Université Libre de Bruxelles (U.L.B.)Hôpital Erasme, Université Libre de Bruxelles (U.L.B.)Institute for Translational VaccinologyInstitut Pasteur de LilleInsermCNRSUniversite Lille Nord de FranceCD4+ T cells are prominent effector cells in controlling Mycobacterium tuberculosis (Mtb) infection but may also contribute to immunopathology. Studies probing the CD4+ T cell response from individuals latently infected with Mtb or patients with active tuberculosis using either small or proteome-wide antigen screens so far revealed a multi-antigenic, yet mostly invariable repertoire of immunogenic Mtb proteins. Recent developments in mass spectrometry-based proteomics have highlighted the occurrence of numerous types of post-translational modifications (PTM) in proteomes of prokaryotes, including Mtb. Well known PTMs in Mtb are glycosylation, lipidation or phosphorylation, known regulators of protein function or compartmentalization. Other PTM include methylation, acetylation and pupylation, involved in protein stability. While all PTM add variability to the Mtb proteome, relatively little is understood about their role in the anti-Mtb immune responses. Here, we review Mtb protein PTMs and methods to assess their role in protective immunity against Mtb.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00361/fullMycobacterium tuberculosisProteomicspost translational modificationCD4+ T cell epitopeimmunoproteomeMHC peptides |
| spellingShingle | Cecile A.C.M. Van Els Veronique eCorbiere Kaat eSmits Jacqueline A.M. van Gaans-van den Brink Martien C.M. Poelen Francoise eMascart Francoise eMascart Hugo D. Meiring Camille eLocht Camille eLocht Camille eLocht Camille eLocht Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome Frontiers in Immunology Mycobacterium tuberculosis Proteomics post translational modification CD4+ T cell epitope immunoproteome MHC peptides |
| title | Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome |
| title_full | Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome |
| title_fullStr | Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome |
| title_full_unstemmed | Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome |
| title_short | Towards understanding the essence of post-translational modifications for the Mycobacterium tuberculosis immunoproteome |
| title_sort | towards understanding the essence of post translational modifications for the mycobacterium tuberculosis immunoproteome |
| topic | Mycobacterium tuberculosis Proteomics post translational modification CD4+ T cell epitope immunoproteome MHC peptides |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00361/full |
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