The Molecular Impacts of Retrotransposons in Development and Diseases
Retrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their <i>cis</i>-regulatory sequences, reverse transcription machinery, and the ability to mold higher-order chrom...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/22/16418 |
| _version_ | 1797458978359214080 |
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| author | Phoebe Lut Fei Tam Danny Leung |
| author_facet | Phoebe Lut Fei Tam Danny Leung |
| author_sort | Phoebe Lut Fei Tam |
| collection | DOAJ |
| description | Retrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their <i>cis</i>-regulatory sequences, reverse transcription machinery, and the ability to mold higher-order chromatin structures. Due to their multifaceted functions, it is crucial for host fitness to maintain strict regulation of these parasitic sequences to ensure proper growth and development. This review explores how subsets of retrotransposons have undergone evolutionary exaptation to enhance the complexity of mammalian genomes. It also highlights the significance of regulating these elements, drawing on recent studies conducted in human and murine systems. |
| first_indexed | 2024-03-09T16:44:54Z |
| format | Article |
| id | doaj.art-529448d638194033888b11958cf0037c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:44:54Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-529448d638194033888b11958cf0037c2023-11-24T14:47:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124221641810.3390/ijms242216418The Molecular Impacts of Retrotransposons in Development and DiseasesPhoebe Lut Fei Tam0Danny Leung1Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, ChinaDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, ChinaRetrotransposons are invasive genetic elements that constitute substantial portions of mammalian genomes. They have the potential to influence nearby gene expression through their <i>cis</i>-regulatory sequences, reverse transcription machinery, and the ability to mold higher-order chromatin structures. Due to their multifaceted functions, it is crucial for host fitness to maintain strict regulation of these parasitic sequences to ensure proper growth and development. This review explores how subsets of retrotransposons have undergone evolutionary exaptation to enhance the complexity of mammalian genomes. It also highlights the significance of regulating these elements, drawing on recent studies conducted in human and murine systems.https://www.mdpi.com/1422-0067/24/22/16418retrotransposonsepigenomicsmammalian developmentdiseases |
| spellingShingle | Phoebe Lut Fei Tam Danny Leung The Molecular Impacts of Retrotransposons in Development and Diseases International Journal of Molecular Sciences retrotransposons epigenomics mammalian development diseases |
| title | The Molecular Impacts of Retrotransposons in Development and Diseases |
| title_full | The Molecular Impacts of Retrotransposons in Development and Diseases |
| title_fullStr | The Molecular Impacts of Retrotransposons in Development and Diseases |
| title_full_unstemmed | The Molecular Impacts of Retrotransposons in Development and Diseases |
| title_short | The Molecular Impacts of Retrotransposons in Development and Diseases |
| title_sort | molecular impacts of retrotransposons in development and diseases |
| topic | retrotransposons epigenomics mammalian development diseases |
| url | https://www.mdpi.com/1422-0067/24/22/16418 |
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