UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation

Abstract Background Radioresistance is the major obstacle in radiation therapy (RT) for hepatocellular carcinoma (HCC). Dysregulation of DNA damage response (DDR), which includes DNA repair and cell cycle checkpoints activation, leads to radioresistance and limits radiotherapy efficacy in HCC patien...

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Bibliographic Details
Main Authors: Jingyuan Sun, Zhenru Zhu, Wenwen Li, Mengying Shen, Chuanhui Cao, Qingcan Sun, Zeqin Guo, Li Liu, Dehua Wu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ubiquitin-conjugating enzyme E2T
H2AX monoubiquitination
Cell cycle arrest
Radioresistance
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-020-01734-4

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