Distribution of G6PD deficiency genotypes among Southeast Asian populations
Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a group of X-linked, hereditary genetic disorders caused by mutations in the G6PD gene and results in functional variants of about 400 biochemical and clinical phenotypes. Among them, more than 215 genotypes have been identified so far....
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Tropical Medicine and Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41182-021-00387-z |
| _version_ | 1819103030755196928 |
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| author | Indah S. Tantular Fumihiko Kawamoto |
| author_facet | Indah S. Tantular Fumihiko Kawamoto |
| author_sort | Indah S. Tantular |
| collection | DOAJ |
| description | Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a group of X-linked, hereditary genetic disorders caused by mutations in the G6PD gene and results in functional variants of about 400 biochemical and clinical phenotypes. Among them, more than 215 genotypes have been identified so far. In this review, specific features of the genotype distribution in different communities and countries are discussed based on multiple reports and our molecular epidemiological studies of Southeast Asian countries. Particularly, in Indonesia, the frequency distribution of G6PD deficiency variants was distinct between western and eastern Indonesian populations, suggesting two different gene flows during Indonesian expansions. |
| first_indexed | 2024-12-22T01:43:59Z |
| format | Article |
| id | doaj.art-529c086b40ad4bd4bdd3b3410e56270c |
| institution | Directory Open Access Journal |
| issn | 1349-4147 |
| language | English |
| last_indexed | 2024-12-22T01:43:59Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Medicine and Health |
| spelling | doaj.art-529c086b40ad4bd4bdd3b3410e56270c2022-12-21T18:43:07ZengBMCTropical Medicine and Health1349-41472021-12-014911710.1186/s41182-021-00387-zDistribution of G6PD deficiency genotypes among Southeast Asian populationsIndah S. Tantular0Fumihiko Kawamoto1Institute of Tropical Disease, Universitas AirlanggaInstitute of Tropical Disease, Universitas AirlanggaAbstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a group of X-linked, hereditary genetic disorders caused by mutations in the G6PD gene and results in functional variants of about 400 biochemical and clinical phenotypes. Among them, more than 215 genotypes have been identified so far. In this review, specific features of the genotype distribution in different communities and countries are discussed based on multiple reports and our molecular epidemiological studies of Southeast Asian countries. Particularly, in Indonesia, the frequency distribution of G6PD deficiency variants was distinct between western and eastern Indonesian populations, suggesting two different gene flows during Indonesian expansions.https://doi.org/10.1186/s41182-021-00387-zGlucose-6-phosphate dehydrogenaseG6PD deficiencyGenotypeDistributionSoutheast Asian population |
| spellingShingle | Indah S. Tantular Fumihiko Kawamoto Distribution of G6PD deficiency genotypes among Southeast Asian populations Tropical Medicine and Health Glucose-6-phosphate dehydrogenase G6PD deficiency Genotype Distribution Southeast Asian population |
| title | Distribution of G6PD deficiency genotypes among Southeast Asian populations |
| title_full | Distribution of G6PD deficiency genotypes among Southeast Asian populations |
| title_fullStr | Distribution of G6PD deficiency genotypes among Southeast Asian populations |
| title_full_unstemmed | Distribution of G6PD deficiency genotypes among Southeast Asian populations |
| title_short | Distribution of G6PD deficiency genotypes among Southeast Asian populations |
| title_sort | distribution of g6pd deficiency genotypes among southeast asian populations |
| topic | Glucose-6-phosphate dehydrogenase G6PD deficiency Genotype Distribution Southeast Asian population |
| url | https://doi.org/10.1186/s41182-021-00387-z |
| work_keys_str_mv | AT indahstantular distributionofg6pddeficiencygenotypesamongsoutheastasianpopulations AT fumihikokawamoto distributionofg6pddeficiencygenotypesamongsoutheastasianpopulations |