Corneal nerve loss predicts dementia in patients with mild cognitive impairment
Abstract Objectives This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). Methods Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, b...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51747 |
| _version_ | 1797845260421824512 |
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| author | Georgios Ponirakis Hanadi Al Hamad Dunya A. M. Omar Ioannis N. Petropoulos Adnan Khan Hoda Gad Mani Chandran Masharig Gadelseed Ahmed Elsotouhy Marwan Ramadan Priya V. Gawhale Marwa Elorrabi Rhia Tosino Ziyad R. Mahfoud Shafi Khan Pravija Manikoth Yasmin H. M. Abdelrahim Mahmoud A. Refaee Noushad Thodi Ahmed Own Ashfaq Shuaib Rayaz A. Malik |
| author_facet | Georgios Ponirakis Hanadi Al Hamad Dunya A. M. Omar Ioannis N. Petropoulos Adnan Khan Hoda Gad Mani Chandran Masharig Gadelseed Ahmed Elsotouhy Marwan Ramadan Priya V. Gawhale Marwa Elorrabi Rhia Tosino Ziyad R. Mahfoud Shafi Khan Pravija Manikoth Yasmin H. M. Abdelrahim Mahmoud A. Refaee Noushad Thodi Ahmed Own Ashfaq Shuaib Rayaz A. Malik |
| author_sort | Georgios Ponirakis |
| collection | DOAJ |
| description | Abstract Objectives This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). Methods Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. Results Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p < 0.0001). Progressors had lower corneal nerve measures, hippocampal, and whole brain volume (all p < 0.0001). However, CCM had a higher prognostic accuracy (72%–75% vs 68%–69%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6–23.8) and 4.1 (95% CI: 1.2–14.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume. Interpretation Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia. Further work is required to validate the predictive ability of CCM compared to other established biomarkers of dementia. |
| first_indexed | 2024-04-09T17:35:53Z |
| format | Article |
| id | doaj.art-529c640a61f34beab621a09cafbca040 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-04-09T17:35:53Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-529c640a61f34beab621a09cafbca0402023-04-17T16:16:03ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-04-0110459960910.1002/acn3.51747Corneal nerve loss predicts dementia in patients with mild cognitive impairmentGeorgios Ponirakis0Hanadi Al Hamad1Dunya A. M. Omar2Ioannis N. Petropoulos3Adnan Khan4Hoda Gad5Mani Chandran6Masharig Gadelseed7Ahmed Elsotouhy8Marwan Ramadan9Priya V. Gawhale10Marwa Elorrabi11Rhia Tosino12Ziyad R. Mahfoud13Shafi Khan14Pravija Manikoth15Yasmin H. M. Abdelrahim16Mahmoud A. Refaee17Noushad Thodi18Ahmed Own19Ashfaq Shuaib20Rayaz A. Malik21Department of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarGeriatric & Memory Clinic Rumailah Hospital, Hamad Medical Corporation Doha QatarMRI Unit Rumailah Hospital, Hamad Medical Corporation Doha QatarNeuroradiology Hamad General Hospital, Hamad Medical Corporation Doha QatarDepartment of Medicine University of Alberta Edmonton Alberta CanadaDepartment of Medicine Weill Cornell Medicine‐Qatar, Qatar Foundation Doha QatarAbstract Objectives This study compared the utility of corneal nerve measures with brain volumetry for predicting progression to dementia in individuals with mild cognitive impairment (MCI). Methods Participants with no cognitive impairment (NCI) and MCI underwent assessment of cognitive function, brain volumetry of thirteen brain structures, including the hippocampus and corneal confocal microscopy (CCM). Participants with MCI were followed up in the clinic to identify progression to dementia. Results Of 107 participants with MCI aged 68.4 ± 7.7 years, 33 (30.8%) progressed to dementia over 2.6‐years of follow‐up. Compared to participants with NCI (n = 12), participants who remained with MCI (n = 74) or progressed to dementia had lower corneal nerve measures (p < 0.0001). Progressors had lower corneal nerve measures, hippocampal, and whole brain volume (all p < 0.0001). However, CCM had a higher prognostic accuracy (72%–75% vs 68%–69%) for identifying individuals who progressed to dementia compared to hippocampus and whole brain volume. The adjusted odds ratio for progression to dementia was 6.1 (95% CI: 1.6–23.8) and 4.1 (95% CI: 1.2–14.2) higher with abnormal CCM measures, but was not significant for abnormal brain volume. Interpretation Abnormal CCM measures have a higher prognostic accuracy than brain volumetry for predicting progression from MCI to dementia. Further work is required to validate the predictive ability of CCM compared to other established biomarkers of dementia.https://doi.org/10.1002/acn3.51747 |
| spellingShingle | Georgios Ponirakis Hanadi Al Hamad Dunya A. M. Omar Ioannis N. Petropoulos Adnan Khan Hoda Gad Mani Chandran Masharig Gadelseed Ahmed Elsotouhy Marwan Ramadan Priya V. Gawhale Marwa Elorrabi Rhia Tosino Ziyad R. Mahfoud Shafi Khan Pravija Manikoth Yasmin H. M. Abdelrahim Mahmoud A. Refaee Noushad Thodi Ahmed Own Ashfaq Shuaib Rayaz A. Malik Corneal nerve loss predicts dementia in patients with mild cognitive impairment Annals of Clinical and Translational Neurology |
| title | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
| title_full | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
| title_fullStr | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
| title_full_unstemmed | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
| title_short | Corneal nerve loss predicts dementia in patients with mild cognitive impairment |
| title_sort | corneal nerve loss predicts dementia in patients with mild cognitive impairment |
| url | https://doi.org/10.1002/acn3.51747 |
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