Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults
Abstract Background Despite a number of respiratory syncytial virus (RSV) vaccine candidates being tested in clinical trials, disease-specific, self-reported instruments assessing symptom severity of RSV infection from the perspective of adult patients are still needed. The RSV Infection, Intensity...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12955-023-02174-2 |
| _version_ | 1797273163204132864 |
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| author | Valerie Williams Carla DeMuro Romano Lyn Finelli Shanshan Qin Todd L. Saretsky Jia Ma Sandy Lewis Matthew Phillips Richard H. Osborne Josephine M. Norquist |
| author_facet | Valerie Williams Carla DeMuro Romano Lyn Finelli Shanshan Qin Todd L. Saretsky Jia Ma Sandy Lewis Matthew Phillips Richard H. Osborne Josephine M. Norquist |
| author_sort | Valerie Williams |
| collection | DOAJ |
| description | Abstract Background Despite a number of respiratory syncytial virus (RSV) vaccine candidates being tested in clinical trials, disease-specific, self-reported instruments assessing symptom severity of RSV infection from the perspective of adult patients are still needed. The RSV Infection, Intensity and Impact Questionnaire (RSV-iiiQ) was adapted from the Influenza Intensity and Impact Questionnaire (FluiiQ™). This study evaluated some measurement properties of the RSV-iiiQ. Methods Data were collected in a web-based survey over two consecutive days. Participants completed the RSV-iiiQ, the Patient Global Impression of Severity, Sheehan Disability Scale, Patient Global Impression of Change, EQ-5D-5L, and a demographic questionnaire. Test-retest reliability, internal consistency, construct validity, and responsiveness of the RSV-iiiQ scales were assessed. Results 111 adults with RSV were enrolled and self-reported a variety of symptoms across the range of disease severity via a web-based platform. The RSV-iiiQ scales demonstrated satisfactory test-retest reliability, construct validity, and discriminating ability. One-factor confirmatory factor analyses confirmed that each of the four scales was sufficiently unidimensional, and internal consistencies indicated that the computation of RSV-iiiQ scale scores was plausible. Correlation-based analyses provided support for the construct validity of the RSV-iiiQ scores, and known groups analyses supported discriminating ability. Estimates of responsiveness of the scale scores were also satisfactory. Conclusions RSV infection is highly symptomatic and causes significant disease burden, and self-report instruments assessing symptom severity and impact are important for evaluation of new treatments. This study describes the preliminary psychometric properties of the RSV-iiiQ and indicates this tool may be useful for the assessment of the severity of symptoms and impact of acute RSV infection in adults. The findings also indicated two items, Runny nose and Ear pain, may be unnecessary and should be revisited using item response theory analysis with a larger sample size. |
| first_indexed | 2024-03-07T14:39:38Z |
| format | Article |
| id | doaj.art-529fe222041240c385c399d2f0052e83 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-03-07T14:39:38Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-529fe222041240c385c399d2f0052e832024-03-05T20:26:08ZengBMCHealth and Quality of Life Outcomes1477-75252024-02-0122111010.1186/s12955-023-02174-2Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adultsValerie Williams0Carla DeMuro Romano1Lyn Finelli2Shanshan Qin3Todd L. Saretsky4Jia Ma5Sandy Lewis6Matthew Phillips7Richard H. Osborne8Josephine M. Norquist9RTI Health SolutionsRTI Health SolutionsMerck & Co., Inc.RTI Health SolutionsMerck & Co., Inc.RTI Health SolutionsRTI Health SolutionsMerck & Co., Inc.Measured Solutions for Health P/LMerck & Co., Inc.Abstract Background Despite a number of respiratory syncytial virus (RSV) vaccine candidates being tested in clinical trials, disease-specific, self-reported instruments assessing symptom severity of RSV infection from the perspective of adult patients are still needed. The RSV Infection, Intensity and Impact Questionnaire (RSV-iiiQ) was adapted from the Influenza Intensity and Impact Questionnaire (FluiiQ™). This study evaluated some measurement properties of the RSV-iiiQ. Methods Data were collected in a web-based survey over two consecutive days. Participants completed the RSV-iiiQ, the Patient Global Impression of Severity, Sheehan Disability Scale, Patient Global Impression of Change, EQ-5D-5L, and a demographic questionnaire. Test-retest reliability, internal consistency, construct validity, and responsiveness of the RSV-iiiQ scales were assessed. Results 111 adults with RSV were enrolled and self-reported a variety of symptoms across the range of disease severity via a web-based platform. The RSV-iiiQ scales demonstrated satisfactory test-retest reliability, construct validity, and discriminating ability. One-factor confirmatory factor analyses confirmed that each of the four scales was sufficiently unidimensional, and internal consistencies indicated that the computation of RSV-iiiQ scale scores was plausible. Correlation-based analyses provided support for the construct validity of the RSV-iiiQ scores, and known groups analyses supported discriminating ability. Estimates of responsiveness of the scale scores were also satisfactory. Conclusions RSV infection is highly symptomatic and causes significant disease burden, and self-report instruments assessing symptom severity and impact are important for evaluation of new treatments. This study describes the preliminary psychometric properties of the RSV-iiiQ and indicates this tool may be useful for the assessment of the severity of symptoms and impact of acute RSV infection in adults. The findings also indicated two items, Runny nose and Ear pain, may be unnecessary and should be revisited using item response theory analysis with a larger sample size.https://doi.org/10.1186/s12955-023-02174-2Respiratory syncytial virus (RSV)RSV infection, intensity and impact questionnaire (RSV-iiiQ)Measurement propertiesSymptomsImpactDisease burden |
| spellingShingle | Valerie Williams Carla DeMuro Romano Lyn Finelli Shanshan Qin Todd L. Saretsky Jia Ma Sandy Lewis Matthew Phillips Richard H. Osborne Josephine M. Norquist Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults Health and Quality of Life Outcomes Respiratory syncytial virus (RSV) RSV infection, intensity and impact questionnaire (RSV-iiiQ) Measurement properties Symptoms Impact Disease burden |
| title | Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults |
| title_full | Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults |
| title_fullStr | Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults |
| title_full_unstemmed | Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults |
| title_short | Psychometric evaluation of the respiratory syncytial virus infection, intensity and impact questionnaire (RSV-iiiQ) in adults |
| title_sort | psychometric evaluation of the respiratory syncytial virus infection intensity and impact questionnaire rsv iiiq in adults |
| topic | Respiratory syncytial virus (RSV) RSV infection, intensity and impact questionnaire (RSV-iiiQ) Measurement properties Symptoms Impact Disease burden |
| url | https://doi.org/10.1186/s12955-023-02174-2 |
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