Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats
<i>Alhagi camelorum</i> (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m<sup>2</sup>) is associated with observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and...
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MDPI AG
2022-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/3/941 |
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| author | Muhammad Omer Iqbal Muhammad Masood Ahmed Shafia Arshad Usman Javaid Imran Ahmad Khan Majid Manzoor Shumaila Andleeb Romana Riaz Shaukat Hussain Munawar Zahid Manzoor Asma Mumtaz |
| author_facet | Muhammad Omer Iqbal Muhammad Masood Ahmed Shafia Arshad Usman Javaid Imran Ahmad Khan Majid Manzoor Shumaila Andleeb Romana Riaz Shaukat Hussain Munawar Zahid Manzoor Asma Mumtaz |
| author_sort | Muhammad Omer Iqbal |
| collection | DOAJ |
| description | <i>Alhagi camelorum</i> (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m<sup>2</sup>) is associated with observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. Remedial measures are needed for the protection of nephrotoxicity against cisplatin. Thus, we investigated the nephroprotective effects of AC plant extract to prevent cisplatin-induced nephrotoxicity in albino Wistar rats. The presence of polyphenols, phenolic compounds, tannins, and saponins was revealed during phytochemical investigation, and a significantly intense antioxidant activity was recorded. There were no toxicological symptoms in the treated rats, and no anatomical, physiological, or histological abnormalities were found compared to the control rats. The results of correcting cisplatin-induced nephrotoxicity revealed that the extract has a significant ability to treat kidney damage, with most parameters returning to normal after only three weeks of therapy. It is concluded that co-administration of cisplatin with AC extract showed exceptional nephroprotective effects at a dose of 600 mg/kg for Cis-induced nephrotoxicity. |
| first_indexed | 2024-03-09T23:27:16Z |
| format | Article |
| id | doaj.art-52a333f78b6a410dae3e3b82619a9859 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:27:16Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-52a333f78b6a410dae3e3b82619a98592023-11-23T17:14:59ZengMDPI AGMolecules1420-30492022-01-0127394110.3390/molecules27030941Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar RatsMuhammad Omer Iqbal0Muhammad Masood Ahmed1Shafia Arshad2Usman Javaid3Imran Ahmad Khan4Majid Manzoor5Shumaila Andleeb6Romana Riaz7Shaukat Hussain Munawar8Zahid Manzoor9Asma Mumtaz10Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaFaculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur 93100, PakistanDepartment of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanFatima Tu Zahara Department of Life Sciences, Muhammad Institute of Medical and Allied Sciences, Multan 60000, PakistanCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaSouthern Punjab Institute of Health Sciences, Multan 60800, PakistanDepartment of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmacology and Toxicology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, PakistanDepartment of Pharmacology and Toxicology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur 63100, PakistanDepartment of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan<i>Alhagi camelorum</i> (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m<sup>2</sup>) is associated with observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. Remedial measures are needed for the protection of nephrotoxicity against cisplatin. Thus, we investigated the nephroprotective effects of AC plant extract to prevent cisplatin-induced nephrotoxicity in albino Wistar rats. The presence of polyphenols, phenolic compounds, tannins, and saponins was revealed during phytochemical investigation, and a significantly intense antioxidant activity was recorded. There were no toxicological symptoms in the treated rats, and no anatomical, physiological, or histological abnormalities were found compared to the control rats. The results of correcting cisplatin-induced nephrotoxicity revealed that the extract has a significant ability to treat kidney damage, with most parameters returning to normal after only three weeks of therapy. It is concluded that co-administration of cisplatin with AC extract showed exceptional nephroprotective effects at a dose of 600 mg/kg for Cis-induced nephrotoxicity.https://www.mdpi.com/1420-3049/27/3/941cisplatinnephrotoxicityreactive oxygen species<i>Alhagi camelorum</i> |
| spellingShingle | Muhammad Omer Iqbal Muhammad Masood Ahmed Shafia Arshad Usman Javaid Imran Ahmad Khan Majid Manzoor Shumaila Andleeb Romana Riaz Shaukat Hussain Munawar Zahid Manzoor Asma Mumtaz Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats Molecules cisplatin nephrotoxicity reactive oxygen species <i>Alhagi camelorum</i> |
| title | Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats |
| title_full | Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats |
| title_fullStr | Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats |
| title_full_unstemmed | Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats |
| title_short | Nephroprotective Effects of <i>Alhagi camelorum</i> against Cisplatin-Induced Nephrotoxicity in Albino Wistar Rats |
| title_sort | nephroprotective effects of i alhagi camelorum i against cisplatin induced nephrotoxicity in albino wistar rats |
| topic | cisplatin nephrotoxicity reactive oxygen species <i>Alhagi camelorum</i> |
| url | https://www.mdpi.com/1420-3049/27/3/941 |
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