Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted...

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Bibliographic Details
Main Authors: Liz J. Valente, Brandon J. Aubrey, Marco J. Herold, Gemma L. Kelly, Lina Happo, Clare L. Scott, Andrea Newbold, Ricky W. Johnstone, David C.S. Huang, Lyubomir T. Vassilev, Andreas Strasser
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716300377

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