Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals....
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2011-08-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-76&slc_lang=en&sid=1 |
| _version_ | 1797280986810023936 |
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| author | Minoo Mahmoodi Nasrin Hashemi-Firouzi Siamak Shahidi |
| author_facet | Minoo Mahmoodi Nasrin Hashemi-Firouzi Siamak Shahidi |
| author_sort | Minoo Mahmoodi |
| collection | DOAJ |
| description | Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice. Methods: Male mice were intraperitoneally (i.p.) administrated sildenafil (1, 2, or 10 mg/kg), and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded. Results: The results indicated that compared to the control group, the sildenafil-treated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group. Discussion: Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/ cGMP/PDE5 pathway. |
| first_indexed | 2024-03-07T16:49:02Z |
| format | Article |
| id | doaj.art-52a6edb37b7d4b9ca9bedd7239d0d656 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:49:02Z |
| publishDate | 2011-08-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-52a6edb37b7d4b9ca9bedd7239d0d6562024-03-03T05:36:32ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422011-08-01245357Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-MazeMinoo MahmoodiNasrin Hashemi-FirouziSiamak ShahidiIntroduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice. Methods: Male mice were intraperitoneally (i.p.) administrated sildenafil (1, 2, or 10 mg/kg), and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded. Results: The results indicated that compared to the control group, the sildenafil-treated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group. Discussion: Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/ cGMP/PDE5 pathway.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-76&slc_lang=en&sid=1AnxietySildenafilAcuteElevated Plus-MazeMice. |
| spellingShingle | Minoo Mahmoodi Nasrin Hashemi-Firouzi Siamak Shahidi Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze Basic and Clinical Neuroscience Anxiety Sildenafil Acute Elevated Plus-Maze Mice. |
| title | Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze |
| title_full | Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze |
| title_fullStr | Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze |
| title_full_unstemmed | Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze |
| title_short | Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze |
| title_sort | modulation of anxiety like behavior in sildenafil citrate treated mice placed in an elevated plus maze |
| topic | Anxiety Sildenafil Acute Elevated Plus-Maze Mice. |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-76&slc_lang=en&sid=1 |
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