Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer
Objective:In this study, we aimed to evaluate the prognostic value of axillary lymph node ratio (LNR) for disease-free survival (DFS) in node positive breast cancer (BC) patients with long term follow-up.Materials and Methods:A total of 179 stage II to III female BC patients, who were followed betwe...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2020-10-01
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| Series: | European Journal of Breast Health |
| Subjects: | |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/lymph-node-ratio-predicts-long-term-survival-in-ly/41892
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| _version_ | 1797916151622139904 |
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| author | Ayşegül Sakin Mehmet Naci Aldemir |
| author_facet | Ayşegül Sakin Mehmet Naci Aldemir |
| author_sort | Ayşegül Sakin |
| collection | DOAJ |
| description | Objective:In this study, we aimed to evaluate the prognostic value of axillary lymph node ratio (LNR) for disease-free survival (DFS) in node positive breast cancer (BC) patients with long term follow-up.Materials and Methods:A total of 179 stage II to III female BC patients, who were followed between December 2001 and January 2019 at the department of medical oncology, were included in this study. Patients were classified into 3 groups based on the LNR as follows; LNR<0.21, LNR=0.21-0.65, and LNR>0.65. SPSS 22 for windows was used for statistical analysis.Results:The median age was 49 (range, 24-83) years. The numbers of patients with stage II and stage III disease were 81 (45.3%) and 98 (54.7%), respectively. The median number of lymph node (LN) resected and positive LN were 15 (range, 3-48) and 3 (range, 1-29), respectively. There were 90 patients (50.3%) with LNR <0.21, 62 (34.6%) with LNR=0.21-0.65, and 27 (15.1%) with LNR >0.65. The median disease-free survival (DFS) was not reached in patients with LNR <0.21, 81 months in patients with LNR=0.21-0.65, and 43 months in patients with LNR>0.65 (p<0.001). Overall survival (OS) was found to be significantly related to LNR (p=0.042). In patients with LNR<0.21 and LNR=0.21-0.65, the median OS was not reached. In patients with LNR >0.65, the median OS was 101 months. In multivariate analysis, LNR=0.21-0.65 (Hazard ratio [HR], 6.99), LNR>0.65 (HR, 28.99), and HER-2 negativity (HR, 4.64) were the factors associated with DFS (p<0.05).Conclusion:LNR is a more useful prognostic factor than the pathological lymph node staging for predicting survival in patients with nod-positive BC. |
| first_indexed | 2024-04-10T12:52:39Z |
| format | Article |
| id | doaj.art-52a7ba48b3274665ae071f94bca2b97e |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T12:52:39Z |
| publishDate | 2020-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-52a7ba48b3274665ae071f94bca2b97e2023-02-15T16:13:39ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312020-10-0116427027510.5152/ejbh.2020.580913049054Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast CancerAyşegül Sakin0Mehmet Naci Aldemir1 Department of Internal medicine, University of Health Sciences, Van Research and Training Hospital, Van, Turkey Department of Medical Oncology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey Objective:In this study, we aimed to evaluate the prognostic value of axillary lymph node ratio (LNR) for disease-free survival (DFS) in node positive breast cancer (BC) patients with long term follow-up.Materials and Methods:A total of 179 stage II to III female BC patients, who were followed between December 2001 and January 2019 at the department of medical oncology, were included in this study. Patients were classified into 3 groups based on the LNR as follows; LNR<0.21, LNR=0.21-0.65, and LNR>0.65. SPSS 22 for windows was used for statistical analysis.Results:The median age was 49 (range, 24-83) years. The numbers of patients with stage II and stage III disease were 81 (45.3%) and 98 (54.7%), respectively. The median number of lymph node (LN) resected and positive LN were 15 (range, 3-48) and 3 (range, 1-29), respectively. There were 90 patients (50.3%) with LNR <0.21, 62 (34.6%) with LNR=0.21-0.65, and 27 (15.1%) with LNR >0.65. The median disease-free survival (DFS) was not reached in patients with LNR <0.21, 81 months in patients with LNR=0.21-0.65, and 43 months in patients with LNR>0.65 (p<0.001). Overall survival (OS) was found to be significantly related to LNR (p=0.042). In patients with LNR<0.21 and LNR=0.21-0.65, the median OS was not reached. In patients with LNR >0.65, the median OS was 101 months. In multivariate analysis, LNR=0.21-0.65 (Hazard ratio [HR], 6.99), LNR>0.65 (HR, 28.99), and HER-2 negativity (HR, 4.64) were the factors associated with DFS (p<0.05).Conclusion:LNR is a more useful prognostic factor than the pathological lymph node staging for predicting survival in patients with nod-positive BC. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/lymph-node-ratio-predicts-long-term-survival-in-ly/41892 breast cancerlymph node ratiosurvival |
| spellingShingle | Ayşegül Sakin Mehmet Naci Aldemir Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer European Journal of Breast Health breast cancer lymph node ratio survival |
| title | Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer |
| title_full | Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer |
| title_fullStr | Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer |
| title_full_unstemmed | Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer |
| title_short | Lymph Node Ratio Predicts Long-Term Survival in Lymph Node-Positive Breast Cancer |
| title_sort | lymph node ratio predicts long term survival in lymph node positive breast cancer |
| topic | breast cancer lymph node ratio survival |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/lymph-node-ratio-predicts-long-term-survival-in-ly/41892
|
| work_keys_str_mv | AT aysegulsakin lymphnoderatiopredictslongtermsurvivalinlymphnodepositivebreastcancer AT mehmetnacialdemir lymphnoderatiopredictslongtermsurvivalinlymphnodepositivebreastcancer |