Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14164-4 |
| _version_ | 1818841452923322368 |
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| author | S. Dong C. Aguirre-Hernandez A. Scrivo C. Eliscovich E. Arias J. J. Bravo-Cordero A. M. Cuervo |
| author_facet | S. Dong C. Aguirre-Hernandez A. Scrivo C. Eliscovich E. Arias J. J. Bravo-Cordero A. M. Cuervo |
| author_sort | S. Dong |
| collection | DOAJ |
| description | Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues. |
| first_indexed | 2024-12-19T04:26:19Z |
| format | Article |
| id | doaj.art-52a95517e904406cabfd76804cb315b6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:26:19Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-52a95517e904406cabfd76804cb315b62022-12-21T20:36:00ZengNature PortfolioNature Communications2041-17232020-01-0111111210.1038/s41467-019-14164-4Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivoS. Dong0C. Aguirre-Hernandez1A. Scrivo2C. Eliscovich3E. Arias4J. J. Bravo-Cordero5A. M. Cuervo6Department of Development and Molecular Biology, Albert Einstein College of MedicineDepartment of Development and Molecular Biology, Albert Einstein College of MedicineDepartment of Development and Molecular Biology, Albert Einstein College of MedicineDepartment of Medicine Marion Liver Research Center, Albert Einstein College of MedicineInstitute for Aging Studies, Albert Einstein College of MedicineDepartment of Medicine, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount SinaiDepartment of Development and Molecular Biology, Albert Einstein College of MedicineChaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.https://doi.org/10.1038/s41467-019-14164-4 |
| spellingShingle | S. Dong C. Aguirre-Hernandez A. Scrivo C. Eliscovich E. Arias J. J. Bravo-Cordero A. M. Cuervo Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo Nature Communications |
| title | Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo |
| title_full | Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo |
| title_fullStr | Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo |
| title_full_unstemmed | Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo |
| title_short | Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo |
| title_sort | monitoring spatiotemporal changes in chaperone mediated autophagy in vivo |
| url | https://doi.org/10.1038/s41467-019-14164-4 |
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