Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer
The effect of marital status (MS) on survival varies according to cancer type and gender. There has been no report on the impact of MS on survival in male breast cancer (MBC). This study aims to determine the influence of MS on tumor stage at diagnosis and survival in MBC. Men with MBC ≥18 years of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-07-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/1557988316669044 |
| _version_ | 1819295211901157376 |
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| author | Orimisan Samuel Adekolujo MD Shourya Tadisina MD Ujwala Koduru MD Jill Gernand MS Susan Jane Smith MD, FACP Radhika Ramani Kakarala MD, MS, FACP |
| author_facet | Orimisan Samuel Adekolujo MD Shourya Tadisina MD Ujwala Koduru MD Jill Gernand MS Susan Jane Smith MD, FACP Radhika Ramani Kakarala MD, MS, FACP |
| author_sort | Orimisan Samuel Adekolujo MD |
| collection | DOAJ |
| description | The effect of marital status (MS) on survival varies according to cancer type and gender. There has been no report on the impact of MS on survival in male breast cancer (MBC). This study aims to determine the influence of MS on tumor stage at diagnosis and survival in MBC. Men with MBC ≥18 years of age in the SEER database from 1990 to 2011 were included in the study. MS was classified as married and unmarried (including single, divorced, separated, widowed). Kaplan–Meier method was used to estimate the 5-year cancer-specific survival. Multivariate regression analyses were done to determine the effect of MS on presence of Stage IV disease at diagnosis and on cancer-specific mortality. The study included 3,761 men; 2,647 (70.4%) were married. Unmarried men were more often diagnosed with Stage IV MBC compared with married (10.7% vs. 5.5%, p < .001). Unmarried men (compared with married) were significantly less likely to undergo surgery (92.4% vs. 96.7%, p < .001). Overall unmarried males with Stages II, III, and IV MBC have significantly worse 5-year cancer-specific survival compared with married. On multivariate analysis, being unmarried was associated with increased hazard of death (HR = 1.43, p < .001) and increased likelihood of Stage IV disease at diagnosis ( OR = 1.96, p < .001). Unmarried males with breast cancer are at greater risk for Stage IV disease at diagnosis and poorer outcomes compared with married males. |
| first_indexed | 2024-12-24T04:38:37Z |
| format | Article |
| id | doaj.art-52ac374920534cc2824396f879094434 |
| institution | Directory Open Access Journal |
| issn | 1557-9883 1557-9891 |
| language | English |
| last_indexed | 2024-12-24T04:38:37Z |
| publishDate | 2017-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-52ac374920534cc2824396f8790944342022-12-21T17:14:57ZengSAGE PublishingAmerican Journal of Men's Health1557-98831557-98912017-07-011110.1177/1557988316669044Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast CancerOrimisan Samuel Adekolujo MD0Shourya Tadisina MD1Ujwala Koduru MD2Jill Gernand MS3Susan Jane Smith MD, FACP4Radhika Ramani Kakarala MD, MS, FACP5Michigan State University, East Lasing, MI, USAMichigan State University, East Lasing, MI, USAMichigan State University, East Lasing, MI, USAMcLaren Flint, Flint, MI, USAMichigan State University, East Lasing, MI, USAMichigan State University, East Lasing, MI, USAThe effect of marital status (MS) on survival varies according to cancer type and gender. There has been no report on the impact of MS on survival in male breast cancer (MBC). This study aims to determine the influence of MS on tumor stage at diagnosis and survival in MBC. Men with MBC ≥18 years of age in the SEER database from 1990 to 2011 were included in the study. MS was classified as married and unmarried (including single, divorced, separated, widowed). Kaplan–Meier method was used to estimate the 5-year cancer-specific survival. Multivariate regression analyses were done to determine the effect of MS on presence of Stage IV disease at diagnosis and on cancer-specific mortality. The study included 3,761 men; 2,647 (70.4%) were married. Unmarried men were more often diagnosed with Stage IV MBC compared with married (10.7% vs. 5.5%, p < .001). Unmarried men (compared with married) were significantly less likely to undergo surgery (92.4% vs. 96.7%, p < .001). Overall unmarried males with Stages II, III, and IV MBC have significantly worse 5-year cancer-specific survival compared with married. On multivariate analysis, being unmarried was associated with increased hazard of death (HR = 1.43, p < .001) and increased likelihood of Stage IV disease at diagnosis ( OR = 1.96, p < .001). Unmarried males with breast cancer are at greater risk for Stage IV disease at diagnosis and poorer outcomes compared with married males.https://doi.org/10.1177/1557988316669044 |
| spellingShingle | Orimisan Samuel Adekolujo MD Shourya Tadisina MD Ujwala Koduru MD Jill Gernand MS Susan Jane Smith MD, FACP Radhika Ramani Kakarala MD, MS, FACP Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer American Journal of Men's Health |
| title | Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer |
| title_full | Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer |
| title_fullStr | Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer |
| title_full_unstemmed | Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer |
| title_short | Impact of Marital Status on Tumor Stage at Diagnosis and on Survival in Male Breast Cancer |
| title_sort | impact of marital status on tumor stage at diagnosis and on survival in male breast cancer |
| url | https://doi.org/10.1177/1557988316669044 |
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