USP39-mediated deubiquitination of Cyclin B1 promotes tumor cell proliferation and glioma progression

Background: The elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. Cyclin B1 expression could be regulated by ubiquitination and deubiquitination. However, the mechanism of how Cyclin B1 is deubiquitinated and its roles in human glioma remain unclear. Methods: Co-...

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Bibliographic Details
Main Authors: Yue Xiao, Xinyi Chen, Weiwei Hu, Wenjing Ma, Qianqian Di, Haimei Tang, Xibao Zhao, Guodong Huang, Weilin Chen
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Translational Oncology
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Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000992