Sex-Related Microglial Perturbation Is Related to Mitochondrial Changes in a Model of Alzheimer’s Disease

Sex-Related Microglial Perturbation Is Related to Mitochondrial Changes in a Model of Alzheimer’s Disease

Many studies implicate microglia in the pathogenesis of Alzheimer’s disease (AD) but precisely how these cells make their impact has not been determined to date. One contributory factor is likely to be the enhanced production of inflammatory mediators and it is now known that microglia with this sec...

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Bibliographic Details
Main Authors: Eoin O’Neill, Virginia Mela, Aline Sayd Gaban, Sibylle Bechet, Aoife McGrath, Aife Walsh, Allison McIntosh, Marina A. Lynch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
microglia
mitochondrial dysfunction
iron accumulation
sex-related differences
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.939830/full

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