Functionalized Β-Cyclodextrin for Smart Drug Delivery Application
In recent years, an emphasis has been established on advanced cancer drug delivery, in order to improve the efficiency of the cancer therapy [1]. Cyclodextrin (CD) is a cyclic oligosaccharide formed by 6, 7, or 8 glucose units by α-1,4 glycosidic bonds, which are called α, β, γ-cyclodextrin, respect...
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MDPI AG
2022-04-01
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| author | Elena-Ruxandra Radu Cristina Stavarache Andreea Madalina Pandele Stefan Ioan Voicu |
| author_facet | Elena-Ruxandra Radu Cristina Stavarache Andreea Madalina Pandele Stefan Ioan Voicu |
| author_sort | Elena-Ruxandra Radu |
| collection | DOAJ |
| description | In recent years, an emphasis has been established on advanced cancer drug delivery, in order to improve the efficiency of the cancer therapy [1]. Cyclodextrin (CD) is a cyclic oligosaccharide formed by 6, 7, or 8 glucose units by α-1,4 glycosidic bonds, which are called α, β, γ-cyclodextrin, respectively [2]. Due to its hollow truncated morphology with a hydrophobic inside and hydrophilic outside, CD has been studied in numerous drug delivery systems [3–5]. In the present study, the modification of β-CD with 3-(Aminopropyl)triethoxysilane (APTES) was investigated. For<strong> </strong>this study we used: β-Cyclodextrin (β-CD) purchased from Fluka, 3-(Aminopropyl) triethoxysilane (APTES) from Sigma Aldrich, NaOH from Roth, dimethylforamide (DMF) from Acros Organics, and acetone from Chimreactiv. Firstly, NaOH, APTES, and DMF were solubilized by magnetic stirring for 1 h at 40 °C. After solubilization, β-CD was added and allowed to react for 2 h, at 40 °C, under magnetic stirring. The functionalized β-CD was precipitated in acetone, and in the end washed and filtered. The sample was dried at room temperature and investigated by NMR. The<strong> </strong><sup>1</sup>H NMR was employed to further demonstrate the molecular structure of β-CD. The obtained NMR spectrum of β-CD shows the presence of characteristic proton peaks. The<strong> </strong>chemical structure of functionalized β-CD was studied, in order to look for possible biomedical applications, such as smart drug delivery systems. |
| first_indexed | 2024-03-11T02:37:46Z |
| format | Article |
| id | doaj.art-52aff4f18003488bb34a19738dfdef29 |
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| language | English |
| last_indexed | 2024-03-11T02:37:46Z |
| publishDate | 2022-04-01 |
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| series | Chemistry Proceedings |
| spelling | doaj.art-52aff4f18003488bb34a19738dfdef292023-11-18T09:47:20ZengMDPI AGChemistry Proceedings2673-45832022-04-01716710.3390/chemproc2022007067Functionalized Β-Cyclodextrin for Smart Drug Delivery ApplicationElena-Ruxandra Radu0Cristina Stavarache1Andreea Madalina Pandele2Stefan Ioan Voicu3National Institute for Research & Development in Chemistry and Petrochemistry—ICECHIM Bucharest, 202 Spl. Independentei, 060021 Bucharest, RomaniaAdvanced Polymers Materials Group, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Str. Gheorghe Polizu 1-7, 011061 Bucharest, RomaniaAdvanced Polymers Materials Group, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Str. Gheorghe Polizu 1-7, 011061 Bucharest, RomaniaFaculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, Str. Gheorghe Polizu 1-7, 011061 Bucharest, RomaniaIn recent years, an emphasis has been established on advanced cancer drug delivery, in order to improve the efficiency of the cancer therapy [1]. Cyclodextrin (CD) is a cyclic oligosaccharide formed by 6, 7, or 8 glucose units by α-1,4 glycosidic bonds, which are called α, β, γ-cyclodextrin, respectively [2]. Due to its hollow truncated morphology with a hydrophobic inside and hydrophilic outside, CD has been studied in numerous drug delivery systems [3–5]. In the present study, the modification of β-CD with 3-(Aminopropyl)triethoxysilane (APTES) was investigated. For<strong> </strong>this study we used: β-Cyclodextrin (β-CD) purchased from Fluka, 3-(Aminopropyl) triethoxysilane (APTES) from Sigma Aldrich, NaOH from Roth, dimethylforamide (DMF) from Acros Organics, and acetone from Chimreactiv. Firstly, NaOH, APTES, and DMF were solubilized by magnetic stirring for 1 h at 40 °C. After solubilization, β-CD was added and allowed to react for 2 h, at 40 °C, under magnetic stirring. The functionalized β-CD was precipitated in acetone, and in the end washed and filtered. The sample was dried at room temperature and investigated by NMR. The<strong> </strong><sup>1</sup>H NMR was employed to further demonstrate the molecular structure of β-CD. The obtained NMR spectrum of β-CD shows the presence of characteristic proton peaks. The<strong> </strong>chemical structure of functionalized β-CD was studied, in order to look for possible biomedical applications, such as smart drug delivery systems.https://www.mdpi.com/2673-4583/7/1/67β-cyclodextrindrug deliverycancer therapy |
| spellingShingle | Elena-Ruxandra Radu Cristina Stavarache Andreea Madalina Pandele Stefan Ioan Voicu Functionalized Β-Cyclodextrin for Smart Drug Delivery Application Chemistry Proceedings β-cyclodextrin drug delivery cancer therapy |
| title | Functionalized Β-Cyclodextrin for Smart Drug Delivery Application |
| title_full | Functionalized Β-Cyclodextrin for Smart Drug Delivery Application |
| title_fullStr | Functionalized Β-Cyclodextrin for Smart Drug Delivery Application |
| title_full_unstemmed | Functionalized Β-Cyclodextrin for Smart Drug Delivery Application |
| title_short | Functionalized Β-Cyclodextrin for Smart Drug Delivery Application |
| title_sort | functionalized β cyclodextrin for smart drug delivery application |
| topic | β-cyclodextrin drug delivery cancer therapy |
| url | https://www.mdpi.com/2673-4583/7/1/67 |
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