The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities
Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14882 |
| _version_ | 1797575746800058368 |
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| author | Haim Werner |
| author_facet | Haim Werner |
| author_sort | Haim Werner |
| collection | DOAJ |
| description | Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor (InsR). The effects of IGF1 are moderated by a group of binding proteins (IGFBPs) that bind and transport the ligand in the circulation and extracellular fluids. In mechanistic terms, IGF1R function is linked to the MAPK and PI3K signaling pathways. Furthermore, IGF1R has been shown to migrate to cell nucleus, where it functions as a transcriptional activator. The co-localization of IGF1R and MAPK in the nucleus is of major interest as it suggests novel mechanistic paradigms for the IGF1R-MAPK network. Given its potent anti-apoptotic and pro-survival roles, and in view of its almost universal pattern of expression in most types of cancer, IGF1R has emerged as a promising molecular target in oncology. The present review article provides a concise overview of key scientific developments in the research area of IGF and highlights a number of more recent findings, including its nuclear migration and its interaction with oncogenes and tumor suppressors. |
| first_indexed | 2024-03-10T21:42:40Z |
| format | Article |
| id | doaj.art-52b01c9be8e04054bf43fd7974ebf5c3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:42:40Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-52b01c9be8e04054bf43fd7974ebf5c32023-11-19T14:32:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124191488210.3390/ijms241914882The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic OpportunitiesHaim Werner0Department of Human Molecular Genetics and Biochemistry, School of Medicine, Tel Aviv University, Tel Aviv 69978, IsraelInsulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor (InsR). The effects of IGF1 are moderated by a group of binding proteins (IGFBPs) that bind and transport the ligand in the circulation and extracellular fluids. In mechanistic terms, IGF1R function is linked to the MAPK and PI3K signaling pathways. Furthermore, IGF1R has been shown to migrate to cell nucleus, where it functions as a transcriptional activator. The co-localization of IGF1R and MAPK in the nucleus is of major interest as it suggests novel mechanistic paradigms for the IGF1R-MAPK network. Given its potent anti-apoptotic and pro-survival roles, and in view of its almost universal pattern of expression in most types of cancer, IGF1R has emerged as a promising molecular target in oncology. The present review article provides a concise overview of key scientific developments in the research area of IGF and highlights a number of more recent findings, including its nuclear migration and its interaction with oncogenes and tumor suppressors.https://www.mdpi.com/1422-0067/24/19/14882insulin-like growth factor-1 (IGF1)IGF1 receptorMAPKnuclear translocationp53 |
| spellingShingle | Haim Werner The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities International Journal of Molecular Sciences insulin-like growth factor-1 (IGF1) IGF1 receptor MAPK nuclear translocation p53 |
| title | The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities |
| title_full | The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities |
| title_fullStr | The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities |
| title_full_unstemmed | The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities |
| title_short | The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities |
| title_sort | igf1 signaling pathway from basic concepts to therapeutic opportunities |
| topic | insulin-like growth factor-1 (IGF1) IGF1 receptor MAPK nuclear translocation p53 |
| url | https://www.mdpi.com/1422-0067/24/19/14882 |
| work_keys_str_mv | AT haimwerner theigf1signalingpathwayfrombasicconceptstotherapeuticopportunities AT haimwerner igf1signalingpathwayfrombasicconceptstotherapeuticopportunities |