The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities

The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities

Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in multiple aspects of growth, development and metabolism. The biological actions of IGF1 are mediated by the IGF1 receptor (IGF1R), a cell-surface protein that is evolutionarily related to the insulin receptor (...

Full description

Bibliographic Details
Main Author:	Haim Werner
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	International Journal of Molecular Sciences
Subjects:	insulin-like growth factor-1 (IGF1) IGF1 receptor MAPK nuclear translocation p53
Online Access:	https://www.mdpi.com/1422-0067/24/19/14882

Similar Items

A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression
by: Martina Chrudinová, et al.
Published: (2024-02-01)

The Role of Nuclear Insulin and IGF1 Receptors in Metabolism and Cancer
by: Haim Werner, et al.
Published: (2021-04-01)

Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns
by: Rive Sarfstein, et al.
Published: (2020-07-01)

Hallmarks of cancer: The insulin-like growth factors perspective
by: Haim Werner, et al.
Published: (2022-11-01)

Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP
by: Karthik Nagaraj, et al.
Published: (2022-10-01)

Unraveling the Resistance of IGF-Pathway Inhibition in Ewing Sarcoma
by: Stefanie de Groot, et al.
Published: (2020-11-01)

Therapeutic Targeting of the IGF Axis
by: Eliot Osher, et al.
Published: (2019-08-01)

The Olfactory Receptor Gene Product, OR5H2, Modulates Endometrial Cancer Cells Proliferation via Interaction with the IGF1 Signaling Pathway
by: Rand Shibel, et al.
Published: (2021-06-01)

The Insulin-like Growth Factor Signaling Pathway in Breast Cancer: An Elusive Therapeutic Target
by: Ji-Sun Lee, et al.
Published: (2022-11-01)

The IGF hormonal network in endometrial cancer: functions, regulation and targeting approaches
by: Ilan eBruchim, et al.
Published: (2014-05-01)

The IGF-1 Signaling Pathway in Viral Infections
by: Agata Józefiak, et al.
Published: (2021-07-01)

ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
by: Laris Achlaug, et al.
Published: (2021-06-01)

The Insulin/IGF system in colorectal cancer development and resistance to therapy
by: Paolo Giovanni Vigneri, et al.
Published: (2015-10-01)

Insulin-like growth factors and aging: lessons from Laron syndrome
by: Haim Werner, et al.
Published: (2023-10-01)

Emerging Role of IGF-1 in Prostate Cancer: A Promising Biomarker and Therapeutic Target
by: Guoqiang Liu, et al.
Published: (2023-02-01)

Obesity and endocrine-related cancer: The important role of IGF-1
by: Wentao Zhong, et al.
Published: (2023-01-01)

Understanding IGF-II Action through Insights into Receptor Binding and Activation
by: Andrew J. Blyth, et al.
Published: (2020-10-01)

BRCA1: An Endocrine and Metabolic Regulator
by: Haim Werner
Published: (2022-03-01)

Association between Expression of Insulin-like Growth Factor-1 (IGF-1), IGF-1 Receptor (IGF-1R), and Hypertension-Mediated Organ Damage (HMOD) Parameters in Leukocytes and Plasma of Children/Adolescents with Primary Hypertension
by: Renata Grzywa-Czuba, et al.
Published: (2024-02-01)

The therapeutic effects of blocking IGF-R1 on mice model of skin cancer
by: Abdullah Alyoussef
Published: (2021-10-01)

The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling
by: Tomoko Okuyama, et al.
Published: (2021-06-01)

Targeting the IGF-Axis in Cultured Pediatric High-Grade Glioma Cells Inhibits Cell Cycle Progression and Survival
by: Yinhsuan Michely Chen, et al.
Published: (2023-02-01)

Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers
by: Hanna Lawnicka, et al.
Published: (2020-03-01)

Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action
by: Rive Sarfstein, et al.
Published: (2022-05-01)

Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
by: Julian Bailes, et al.
Published: (2021-02-01)

Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis
by: J. Nagasao, et al.
Published: (2022-10-01)

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways
by: Haim Werner, et al.
Published: (2019-06-01)

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications
by: Małgorzata Woronkowicz, et al.
Published: (2024-02-01)

IGF-binding proteins in type 1 diabetes are more severely altered in the presence of complications
by: Ashok eSharma, et al.
Published: (2016-01-01)

New Insights from IGF-IR Stimulating Activity Analyses: Pathological Considerations
by: Joseph A.M.J.L. Janssen
Published: (2020-04-01)

Disrupting Insulin and IGF Receptor Function in Cancer
by: Jingran Cao, et al.
Published: (2021-01-01)

Secretion of parathyroid hormone may be coupled to insulin secretion in humans
by: Marie Reeberg Sass, et al.
Published: (2020-08-01)

The IGF2/IGF1R/Nanog Signaling Pathway Regulates the Proliferation of Acute Myeloid Leukemia Stem Cells
by: Dan-dan Xu, et al.
Published: (2018-06-01)

Characterization and expression analysis of gonad specific igf3 in the medaka ovary
by: Jiale Xie, et al.
Published: (2022-05-01)

IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells
by: Damiano Cosimo Rigiracciolo, et al.
Published: (2020-04-01)

IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy
by: Amal Al-Eisa, et al.
Published: (2017-06-01)

IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review
by: Justyna Szydlowska-Gladysz, et al.
Published: (2024-04-01)

Pleiotropic Effects of IGF1 on the Oocyte
by: Paweł Kordowitzki, et al.
Published: (2022-05-01)

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?
by: Baptiste Ameline, et al.
Published: (2021-03-01)

Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer
by: Aldona Kasprzak
Published: (2021-06-01)