Hepatocyte permissiveness to Plasmodium infection is conveyed by a short and structurally conserved region of the CD81 large extracellular domain.
Invasion of hepatocytes by Plasmodium sporozoites is a prerequisite for establishment of a malaria infection, and thus represents an attractive target for anti-malarial interventions. Still, the molecular mechanisms underlying sporozoite invasion are largely unknown. We have previously reported that...
Main Authors: | Samir Yalaoui, Sergine Zougbédé, Stéphanie Charrin, Olivier Silvie, Cécile Arduise, Khemais Farhati, Claude Boucheix, Dominique Mazier, Eric Rubinstein, Patrick Froissard |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-02-01
|
Series: | PLoS Pathogens |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18389082/?tool=EBI |
Similar Items
-
Temperature shift and host cell contact up-regulate sporozoite expression of Plasmodium falciparum genes involved in hepatocyte infection.
by: Anthony Siau, et al.
Published: (2008-08-01) -
The Host Protein Aquaporin-9 is Required for Efficient Plasmodium falciparum Sporozoite Entry into Human Hepatocytes
by: Nadia Amanzougaghene, et al.
Published: (2021-06-01) -
Intravital observation of Plasmodium berghei sporozoite infection of the liver.
by: Ute Frevert, et al.
Published: (2005-06-01) -
Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.
by: Ben C L van Schaijk, et al.
Published: (2008-01-01) -
Plasmodium sporozoites can invade hepatocytic cells independently of the Ephrin receptor A2.
by: Anne-Claire Langlois, et al.
Published: (2018-01-01)